Type‐specific persistence and clearance rates of <scp>HPV</scp> genotypes in the oral and oropharyngeal mucosa in an <scp>HIV</scp>/<scp>AIDS</scp> cohort

Castillejos-García, Itzel; Ramírez‐Amador, Velia; Carrillo-García, Adela; García‐Carrancá, Alejandro; Lizano, Marcela; Anaya‐Saavedra, Gabriela

doi:10.1111/jop.12687

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…"In individuals infected with the human immunodeficiency virus (HIV), oral HPV infection appears to persist for a longer duration compared to their healthy counterparts" [5,6]. "Multiple studies have consistently demonstrated a heightened prevalence and incidence of HPV infection in HIV-infected patients when compared to non-HIV controls" [7][8][9]. "Another significant consideration for individuals living with the HIV virus is the utilization of antiretroviral therapy (ART), the standard treatment for HIV infection, involving a combination of medications" [10].…”

Section: Introductionmentioning

confidence: 99%

Oral Human Papillomavirus Infection in HIV-infected Individuals- A Systematic Review and Meta-analysis

Ferreira,

Véras,

Santana

et al. 2023

JAMMR

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Background: Human papillomavirus (HPV) is the most prevalent sexually transmitted infection globally. Some studies demonstrate that the prevalence and incidence of HPV infection are higher in HIV-infected patients compared to non-HIV controls. This study aims to conduct a systematic review with meta-analysis to assess the prevalence of HPV among HIV-positive individuals. Methodology: We followed the guidelines of the preferred reporting items for systematic reviews and meta-analyses (PRISMA) to conduct a thorough review. We searched for published literature in MEDLINE/PubMed, EMBASE and Scopus, using the following keywords: “HPV”, “papillomavirus”, “papillomaviridae”, “head and neck”, “oropharynx”, “oropharyngeal”, “tongue”, “mouth”, “oral”, “oral cavity”, “HIV”, “Acquired Immunodeficiency Syndrome” and “AIDS”. Out of 925 studies, we included 26 in our analysis. Results: A total of 925 studies were retrieved using our search strategy, with 26 studies meeting the inclusion criteria for this systematic review. The pooled analysis revealed an overall prevalence of oral HPV infection in HIV-infected individuals at 24.00% (95% confidence interval: 16.00-35.00). Conclusion: This systematic review highlights a notable prevalence of oral HPV infection among individuals living with HIV. These findings underscore the importance of continued research and public health efforts to address the intersection of HIV and HPV, contributing to a comprehensive understanding of the epidemiology and potential implications for preventive strategies in this vulnerable population.

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Section: Introductionmentioning

confidence: 99%

Oral Human Papillomavirus Infection in HIV-infected Individuals- A Systematic Review and Meta-analysis

Ferreira,

Véras,

Santana

et al. 2023

JAMMR

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“…The incidence of head and neck cancer squamous cell carcinoma (HNSCC) is rapidly increasing in both PLWH and the general population due to a rise in oropharyngeal HNSCC associated with the human papillomavirus (HPV) 7 . PLWH have higher rates of incident HPV infection but with lower rates of clearance than people who are HIV‐negative 8,9 . One study found that among veterans living with HIV, oropharyngeal HNSCC incidence had increased from 6.8 cases per 100,000 person‐years in 1996–2000 to 11.4 per 100,000 person‐years in 2006–2009 7 .…”

Section: Introductionmentioning

confidence: 99%

“…7 PLWH have higher rates of incident HPV infection but with lower rates of clearance than people who are HIV-negative. 8,9 One study found that among veterans living with HIV, oropharyngeal HNSCC incidence had increased from 6.8 cases per 100,000 person-years in 1996-2000 to 11.4 per 100,000 person-years in 2006-2009. 7 This higher disease burden combined with continually increasing numbers of PLWH is culminating in increasingly common and complex interactions between HNSCC and HIV.…”

Section: Introductionmentioning

confidence: 99%

Risk and incidence of head and neck cancers in veterans living with HIV and matched HIV‐negative veterans

Mazul

Hartman

Mowery

et al. 2022

Cancer

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BACKGROUND:Persons living with HIV/AIDS have a higher incidence of virus-related and tobacco/alcohol-related cancers. This study is the first to estimate the effect of HIV versus HIV-negative veterans on the risk of head and neck squamous cell carcinoma incidence in a large retrospective cohort study. METHODS: The authors constructed a retrospective cohort study using patient data from 1999 to 2016 from the National Veterans Administration Corporate Data Warehouse and the VA Central Cancer Registry. This cohort study included 45,052 veterans living with HIV/AIDS and 162,486 HIV-negative patients matched by age, sex, and index visit (i.e., HIV diagnosis date or clinic visit date). The age-standardized incidence rates and estimated adjusted hazard ratios were calculated with a Cox proportional hazards regression for oropharyngeal and nonoropharyngeal head and neck cancer squamous cell carcinoma (HNSCC). The authors also abstracted human papillomavirus (HPV) status from oropharyngeal HNSCC diagnosed after 2010. RESULTS: Veterans living with HIV/AIDS (VLWH) have 1.71 (95% confidence interval [CI], 1.36, 2.14) times the risk of oropharyngeal cancer and 2.06 (95% CI, 1.76, 2.42) times the hazard of nonoropharyngeal cancer compared with HIV-negative veterans. VLWH with oropharyngeal squamous cell carcinoma (OPSCC) were more likely to be HPV-positive (N = 30 [81.1%]) than the HIV-negative veterans with OPSCC (N = 50 [67.6%]), although this difference was not significant (p = .135). For nonoropharyngeal cancer, the increased risk of oral cavity cancer among VLWH drove the increased risk. CONCLUSIONS:The study results suggest that HIV may play a role in virally mediated and nonvirally mediated HNSCC. As the HIV prevalence rises in the United States due to better survival and the incidence of HPV-positive oropharyngeal HNSCC increases, the interaction between HPV and HIV becomes increasingly relevant.

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“…Co-factors like smoking and immunosuppression were reported to play a meaningful role in the process of HPV-persistence [3,4]. Studies in the past reported that a co-existence of HPV with sexually transmitted infections (STIs) facilitates the persistence and dysplastic transformations of HPV-associated lesions in the cervix or the anus [5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The Role of HPV and Non-HPV Sexually Transmitted Infections in Patients with Oropharyngeal Carcinoma: A Case Control Study

Kofler

Laimer

Bruckmoser³

et al. 2020

Cancers

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Background: Certain high-risk (hr) types of human papillomavirus (HPV) can cause cervical cancer in women and penile cancer in men. Hr-HPV can also cause cancers of the oropharynx and anus in both sexes. In the anal and cervical region, a contribution of co-infections with Ureaplasma spp. on the persistence of the hr-HPV infection by a profound inflammatory state is suggested. Here, we investigated if non-HPV sexually transmitted infections are associated with oropharyngeal carcinoma (OPC). Materials and Methods: In this case-control study, a brush test directly from the tumor surface of OPC patients (study group) and from the oropharynx of healthy volunteers (control group), both groups matching in age and sex, was performed. HPV subtypes were detected using a commercially available test kit. For non-HPV sexually transmitted infections (Ureaplasma spp., Chlamydia trachomatis, Mycoplasma hominis, and Mycoplasma genitalium), a multiplex nucleic acid amplification approach was performed. Results: In the study group, 96 patients (23 female/73 male), with histologically confirmed OPC and in the control group 112 patients (19 female/93 male), were included. Oropharyngeal hr-HPV-positivity was detected in 68% (65/96 patients) of the study group and 1.8% (2/112 patients) of the control group (p < 0.001). In three patients in the study group, Ureaplasma spp. was detected, whereas no patient was Ureaplasma spp. positive in the control group (p = 0.097). Chlamydia trachomatis, Mycoplasma hominis, and Mycoplasma genitalium were negative in both groups. Conclusion: Based on the current study, the prevalence of oropharyngeal Ureaplasma spp. among patients with OPC is low and does not support a role in oropharyngeal cancer. However, the detection of the pathogen only among OPC patients but not in the healthy individuals might indicate a potential role and needs further elucidation.

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Type‐specific persistence and clearance rates of HPV genotypes in the oral and oropharyngeal mucosa in an HIV/AIDS cohort

Abstract: Although HR-HPV persistence was low, and clearance of the infection was observed in most cases, a close follow-up is necessary, given the increase in HNC among HIV-subjects, particularly HPV-related cancer.

Cited by 6 publications

References 30 publications

Oral Human Papillomavirus Infection in HIV-infected Individuals- A Systematic Review and Meta-analysis

Oral Human Papillomavirus Infection in HIV-infected Individuals- A Systematic Review and Meta-analysis

Risk and incidence of head and neck cancers in veterans living with HIV and matched HIV‐negative veterans

The Role of HPV and Non-HPV Sexually Transmitted Infections in Patients with Oropharyngeal Carcinoma: A Case Control Study

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