Type-VI Collagen as a Major Component in the Interstitial Matrix of Cutaneous Mechanoreceptors.

Tachibana, Tamiko; Iida, Shūichi; Nawa, Tokio

doi:10.1679/aohc.58.507

Cited by 8 publications

(3 citation statements)

References 20 publications

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“…In between the nerve fibers and lamellar cells, there is a fine network of collagen fibers. Tachibana (1995),13 stained collagen of Mc immunohistochemically and reported that collagen present in Mc is of type VI.CONCLUSIONFrom the above we conclude that structurally Mc is a complex structure consisting of capsule of collagen fibers in which are interspersed fibrocyte variety of capsular cells and core formed of ascending spirals of nerve fibers, collagen fibers and lamellar cells. The nerve fibers inside the core are of three types: neuro-fibrillar networks, varicosities and end bulbs.…”

supporting

confidence: 56%

Structural organization and pattern of innervations of human Meissner's corpuscle: a light microscopic study

et al. 2013

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Background: Human glabrous skin has very rich nerve supply in the form of specialized nerve endings like Meissner's corpuscles, Pacinian corpuscles, Krause end bulbs etc for carrying sensory information to brain. Aim of study: To study the structure, pattern of innervations and nerve terminations of human Meissner's corpuscle. Methods: Skin samples from sixty human beings (age range 2 to 72 years) were taken, sections prepared and stained with a cytological (Haematoxylin-Eosin and Vongieson's stains) and a neural stain (Silver Impregnation). Results: With cytological stain, Meissner's corpuscles were seen in dermal papillae of glabrous skin, each consisting of a cellular structure having a peripheral capsule and central core of transversely arranged cells. With neural stain, each corpuscle was seen to be oval, globular or cylindrical structure, having a capsule surrounding the core of spirally arranged nerve fibers, sandwiched by Schwann cells. In between nerve fibers of the core were seen small bundles of collagen fibers. 2-6 nerve fibers innervated each Mc from the sub corial plexus of nerves and formed various patterns of nerve endings like networks, end bulbs and varicosities inside the Meissner's corpuscle. Conclusion: Meissner's corpuscle is a complex structure composed of capsule-consisting of spindle shaped capsular cells interspersed in collagen fibers, surrounding a core of helically arranged nerve fibers, Schwann cells and collagen fibers.

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confidence: 56%

Structural organization and pattern of innervations of human Meissner's corpuscle: a light microscopic study

et al. 2013

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“…3C,D). These cross-striated structures have been reported in the cytoplasm of terminal Schwann cells of the periodontal Ruffini endings (Beertsen et al, 1974;Kannari, 1990) as well as cutaneous Ruffini endings (Tachibana et al, 1995), indicating that these spindle-shaped cells are terminal Schwann cells. A cell proliferation assay showed that ordinary Schwann cells within the distal stump of the injured IAN proliferated extensively, but that the terminal Schwann cells in the ARP and migrating Schwann cells in the shear zone and TRP did not undergo proliferation after injury to the IAN, indicating that the S-100 immunoreactive spindle-shaped cells appearing in the shear zone and TRP originate from terminal Schwann cells in the ARP without proliferation.…”

Section: Regeneration Of Periodontal Ruffini Endings Of the Adultmentioning

confidence: 57%

Regeneration of periodontal Ruffini endings in adults and neonates

Wakisaka

Atsumi

2003

Microscopy Res & Technique

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We reviewed the regeneration of periodontal Ruffini endings, primary mechanoreceptors in the periodontal ligament, following injury to the inferior alveolar nerve (IAN) in adult and neonatal rats. Morphologically, mature Ruffini endings are characterized by an extensive arborization of axonal terminals and association with specialized Schwann cells, called lamellar or terminal Schwann cells. Following injury to IAN in the adult, the periodontal Ruffini endings of the rat lower incisor ligament regenerate more rapidly than Ruffini endings in other tissues. During regeneration, terminal Schwann cells migrate into regions where they are never found under normal conditions. The development of periodontal Ruffini endings of the rat incisor is closely associated with the eruption of the teeth; the morphology and distribution of the terminal Schwann cells became almost identical to those in adults during postnatal days 15-18 (PN 15-18d) when the first molars appear in the oral cavity, while the axonal elements showed extensive ramification around PN 28d when the functional occlusion commences. When the IAN was injured in neonates, the regeneration of periodontal Ruffini endings was delayed compared with the adults. The migration of terminal Schwann cells is also observed following IAN injury, after which the distribution of terminal Schwann cells became almost identical to that of the adults, i.e., PN 14d. Since the interaction between axon and Schwann cell is important during regeneration and development, further studies are required to elucidate its molecular mechanism during the regeneration as well as the development of the periodontal Ruffini endings.

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“…1991b; Shikata et al. 1993), the palate (Tachibana et al. 1995), the buccal mucosa and the tongue (Becker et al.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical analysis of the distribution of type VI collagen in the lingual mucosa of rats during the morphogenesis of filiform papillae

2010

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Iwasaki, S., Yoshizawa, H. and Aoyagi, H. 2012. Immunohistochemical analysis of the distribution of type VI collagen in the lingual mucosa of rats during the morphogenesis of filiform papillae. -Acta Zoologica (Stockholm) 93: 80-87.We examined the distribution after immunostaining of immunofluorescence of type VI collagen, differential interference contrast (DIC) images, and images obtained using confocal laser-scanning microscopy in transmission mode, after toluidine blue staining, during morphogenesis of the filiform papillae, keratinization of the lingual epithelium and myogenesis in the rat tongue on semi-ultrathin sections of epoxy resin-embedded samples. Immunoreactivity specific for type VI collagen was dispersed over a relatively wide range of connective tissue in the mesenchyme of fetuses on day 15 after conception (E15), at which time the lingual epithelium was composed of one or two layers of cuboidal cells and the lingual muscle was barely recognizable. Slight immunoreactivity specific for type VI collagen was scattered within the lamina propria in fetuses on E17 and on E19, and immunoreactivity was relatively distinct on the connective tissue around the lingual muscle during myogenesis. In fetuses on E19, the epithelium was already stratified squamous. At postnatal stages from P0 to P14, keratinization of the lingual epithelium advanced gradually as morphogenesis of the filiform papillae proceeded during postnatal development. In newborns on P0, myogenesis of the tongue was almost completed. The intensity of immunoreactivity specific for type VI collagen at postnatal stages was mainly restricted on the endomysium and perimysium around the lingual muscle, while scant immunoreactivity was evident in the connective tissue in the lamina propria. Immunoreactivity around the fully mature lingual muscle on P7 and P14 was weaker than that on E19 and P0. Thus, type VI collagen appeared in the connective tissue that surrounded the lingual muscles such as the endomysium and perimysium, in parallel with changes in extracellular components during myogenesis of the tongue.Shin-ichi Iwasaki,

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Type-VI Collagen as a Major Component in the Interstitial Matrix of Cutaneous Mechanoreceptors.

Cited by 8 publications

References 20 publications

Structural organization and pattern of innervations of human Meissner's corpuscle: a light microscopic study

Structural organization and pattern of innervations of human Meissner's corpuscle: a light microscopic study

Regeneration of periodontal Ruffini endings in adults and neonates

Immunohistochemical analysis of the distribution of type VI collagen in the lingual mucosa of rats during the morphogenesis of filiform papillae

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