Types and distribution of congenital heart defects associated with trisomy 21 in Singapore

Tan, Monica; Xu, Cunzhi; Sim, Sarah K R; Seow, Adeline; Tan, Teng Hong; Quek, Swee Chye

doi:10.1111/jpc.12129

Cited by 12 publications

(12 citation statements)

References 15 publications

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“…Congenital heart defects have been reported at a rate of 40-60% (3,6). Association of CHD is one of the most important predictive factor affecting morbidity and mortality in these patients (5).…”

Section: Discussionmentioning

confidence: 99%

“…AVSD has been reported as the most common congenital heart defect in children with DS (3). On the other hand, studies reported that prevalence and distribution of CHD among children with DS varies by regions and ethnic groups (3)(4)(5). The studies from western countries reported AVSD as the frequent defect in DS (3).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to the western countries, the most prevalent pathology is VSD in Asian countries with the rates of 39.2-52.9% (3). The prevalence of AVSD in Asian countries decreases to 11.8-22%, whereas secundum ASD and TOF were found as 11-23.4% and 3.5-13.4%, respectively (3,8,9). In a study reporting a large cohort of 385 patients from Singapore, PDA was reported as the second most common lesion preceded by VSD with a rate of 34.3% (3).…”

Section: Discussionmentioning

confidence: 99%

“…However, studies performed in different populations indicated a wide variability in the distribution of congenital heart defects. While the most prevalent pathology in the western countries is AVSD, ventricular septal defect (VSD) has been reported as the most common congenital heart defect in the Asian societies (3,4). In the present study, we aimed to investigate the prevalence and distribution of congenital heart defects in neonates with Down syndrome (DS) in Southeastern Anatolian Region of Turkey.…”

Section: Introductionmentioning

confidence: 99%

“…The most common pathology is atrioventricular septal defect (AVSD) (3). However, studies performed in different populations indicated a wide variability in the distribution of congenital heart defects.…”

Section: Introductionmentioning

confidence: 99%

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Türkiye'nin Güneydoğu Anadolu Bölgesi'ndeki Down sendromlu yenidoğanlarda konjenital kalp hastalığı prevalansı ve dağılımı

Aldudak¹,

Çelik²,

Akar³

et al. 2016

Ege Tıp Dergisi

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Aim: The prevalence of congenital heart disease (CHD) was reported as 40-60% in patients with Down syndrome (DS). As the prevalence and distribution of congenital heart defects in DS varies according to population and ethnicity, we aimed to investigate CHD in patients with DS in Southeastern Anatolian Region.Materials and Methods: DS cases who were followed-up in neonatal intensive care unit between 2011 and 2013 were included. An experienced pediatric cardiologist examined all cases by transthoracic echocardiography using GE Vivid 3 device. Hospital records of all patients were reviewed.Results: A total of 87 neonates (53 males) were evaluated. The mean age of the presentation was 8.6±5.2 days (range 0-30 days). The number of patients with CHD was 57 (65.5%); one defect in 37 cases (64.9%), two defects in 16 cases (28%), and three defects together in 4 cases (7%). The distribution of CHD in patients revealed atrioventricular septal defect (AVSD) in 23 patients (29.8%), ventricular septal defect (VSD) in 22 patients (28.5%), secundum atrial septal defect in 18 patients (23.3%), patent ductus arteriosus in 11 patients (14.2%), and tetralogy of Fallot in 1, univentricular heart in 1, and intermittent aortic arc in 1 patient. Conclusion:To the best of our knowledge, this is the first study performed only on neonates with DS. The most common defect was AVSD although incidence of VSD was higher than expected. Performing CHD screening during neonatal period is more reliable in patients with DS. The variation in the prevalence and distribution of CHD indicates regional and ethnic variability among patients with DS.Keywords: Congenital heart disease, Down syndrome, neonate. Öz Amaç: Down sendromlu (DS) hastalarda konjenital kalp hastalığı (KKH) sıklığı %40-60 arasında değişmektedir. Down sendromlu hastalarda KKH sıklığı ve dağılımı toplumlara ve etnik kökene göre farklılık gösterebildiğinden bu çalışmada, Güneydoğu Anadolu Bölgesi'nde DS olan yenidoğanlarda KKH sıklığını ve dağılımını incelemeyi amaçladık. Gereç ve

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Türkiye'nin Güneydoğu Anadolu Bölgesi'ndeki Down sendromlu yenidoğanlarda konjenital kalp hastalığı prevalansı ve dağılımı

Aldudak¹,

Çelik²,

Akar³

et al. 2016

Ege Tıp Dergisi

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Maternal risk factors for congenital heart defects in infants with Down syndrome from Western Mexico

Corona‐Rivera

Nieto-García

Gutiérrez‐Chávez

et al. 2019

American J of Med Genetics Pt A

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Atrioventricular septal defects (AVSDs) have been identified as intriguingly infrequent among Hispanics with Down syndrome (DS) born in the United States. The aim of this study was to evaluate the effect of possible maternal risk factors in the presence of congenital heart defects (CHDs) in Mexican infants with DS. A total of 231 live birth infants born with DS during 2009-2018 at the "Dr. Juan I. Menchaca"Civil Hospital of Guadalajara (Guadalajara, Mexico) were ascertained in a casecontrol study. Patients with DS with any major CHD were included as cases and those without major CHD as controls. Potential risk factors were analyzed using logistic regression. Of eligible infants with DS, 100 (43.3%) had ≥1 major CHDs (cases) and were compared with a control group of 131 infants (56.7%) with DS without CHDs. Prevalent CHDs were ostium secundum atrial septal defects (ASDs) (46.9%), ventricular septal defects (27.3%), and AVSDs (14%). Lack of folic acid supplementation before pregnancy had a significant risk for CHDs in infants with DS (adjusted odds ratio [aORs] = 2.9 (95% confidence interval [95% CI]: 1.0-8.6) and in the analysis by subtype of CHDs, also, for the occurrence of ASDs (aOR = 11.5, 95% CI: 1.4-94.4). Almost half of the infants with DS in our sample had CHDs, being ASD the commonest subtype and AVSD the rarest. Our ethnic background alone or in concomitance with observed nutritional disadvantages seems to contribute differences in CHD subtype rates in our DS patients. K E Y W O R D S atrioventricular septal defect, ethnicity, Hispanics, maternal obesity, ostium secundum atrial septal defects

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Down Syndrome

Jensen,

Bulova,

Santoro

2024

Care of Adults With Chronic Childhood Conditions

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Types and distribution of congenital heart defects associated with trisomy 21 in Singapore

Abstract: VSD was the most common congenital heart defect seen in trisomy 21 in our study. A high proportion (25.0%) of trisomy 21 patients with tetralogy of Fallot also had AVSDs.

Cited by 12 publications

References 15 publications

Türkiye'nin Güneydoğu Anadolu Bölgesi'ndeki Down sendromlu yenidoğanlarda konjenital kalp hastalığı prevalansı ve dağılımı

Türkiye'nin Güneydoğu Anadolu Bölgesi'ndeki Down sendromlu yenidoğanlarda konjenital kalp hastalığı prevalansı ve dağılımı

Maternal risk factors for congenital heart defects in infants with Down syndrome from Western Mexico

Down Syndrome

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