Types and frequency of errors in the preparation and administration of drugs

Mendes, Josiane Ribeiro; Lopes, Maria Carolina Barbosa Teixeira; Campanharo, Cássia Regina Vancini; Okuno, Meiry Fernanda Pinto; Batista, Ruth Ester Assayag

doi:10.1590/s1679-45082018ao4146

Cited by 65 publications

(83 citation statements)

References 11 publications

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“…For nursing technicians and assistants, the variables related to direct assistance to the user obtained the highest factor loadings. This means that these workers are more prone to illness and care errors due to their high workload (14)(15) .…”

Section: Discussionmentioning

confidence: 99%

Intensity of nursing work in public hospitals

Santos

Sampaio

et al. 2020

Rev. Latino-Am. Enfermagem

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Objective: to analyze the intensity of nursing work in public hospitals. Method: cross-sectional, quantitative study, carried out in 22 public hospitals. The sample was composed of 265 nurses and 810 nursing technicians and assistants. Data were collected through a questionnaire and analyzed with Exploratory Factor Analysis. The calculation of the distribution of the work intensity by category was done using a score ranging from -1 to +1 standard deviation of the data. Fisher’s exact test (0.05 <p≤0.10) was used to observe the significance between groups according to the employment bond. Results: work intensity contributed to the explanation of precarization of work, with a value of 13% for nurses and 51.2% for technicians and assistants. For the technicians and assistants, the variables with the highest factor loadings were ‘work requires more than she can do’ (0.6696) and ‘takes on multiple tasks due to staff shortages’ (0.6156). Among nurses, the highest factor loadings were observed in the variables ‘time pressure at work (0.6779) and ‘Work pace’ (0.6651). Conclusion: the variables analyzed indicate that work intensity occurs differently among nursing workers, and is revealed by the versatility, understaffing and flexibility of work.

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Section: Discussionmentioning

confidence: 99%

Intensity of nursing work in public hospitals

Santos

Sampaio

et al. 2020

Rev. Latino-Am. Enfermagem

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“…Risk minimization in coadministration of injectable drugs remains important because polymedication is common practice in various patient groups like cancer patients, transplant patients and intensive care patients (neonatal, paediatric, adult). In recent reports, rates of compatibility varied from 9 to 42 % and of incompatibilities from 15 to 68 % [20][21][22][23][24]. Hospital pharmacists should not only answer questions regarding drug-drug compatibilities, but develop together with physicians and nurses incompatibility-reducing infusion schemes to be used in vulnerable patient groups.…”

Section: Discussionmentioning

confidence: 99%

European Databases on Stability and Compatibility of Injectable Medicinal Products in Europe

Hecq

Krämer

Vigneron

2020

Pharmaceutical Technology in Hospital Pharmacy

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AbstractIn hospitals, the majority of medication therapy is administered intravenously. Especially, in intensive care units, simultaneous of various injectable drugs is a common practice Drug incompatibilities have been reported to be associated with up to 60 % of all serious and life-threatening adverse drug events. Several databases are used by hospital pharmacists to answer the questions of (in)compatibility of co-administered injectable drugs. The objective of this article is to present the European databases on compatibility and stability of injectable drugs. According to a questionnaire which was sent to the National Hospital Pharmacy Associations of the 28 countries of European Community there are three national databases available in EU countries which are in alphabetical order, Belgium, France and Germany. The Belgian database is dedicated to injectable medications, is updated and distributed annually in French language on a USB key. STABILIS® is an international database giving information with pictograms translated into 29 languages. This database contains also monographs of non-injectable drugs. The internet-based ADKA STABIL-Datenbank is focused on anticancer drug therapy, listing detailed datasets in German language on stability and compatibility including the references.

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“…Other recent studies performed in adult patients exposed to multiple IV drugs have found incompatible combinations in 12% to 56%. 19,20 However, these differences can be explained using different references and methods. Contrary to other similar studies, we did not exclude any drugs or infusions (i.e., we collected data of all continuous infusions, including electrolytes, PN, and blood products).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Incompatible Coadministration of Continuous Intravenous Infusions in a Pediatric/Neonatal Intensive Care Unit

Häni

Vonbach

Fonzo-Christe

et al. 2019

The Journal of Pediatric Pharmacology and Therapeutics

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OBJECTIVES We aimed to evaluate and quantify incompatible coadministrations of continuous intravenous medication in the daily clinical practice of a PICU/NICU. METHODS We conducted a retrospective, observational study in the setting of an 18-bed PICU/NICU. All concurrently administered continuous infusions, including blood products and parenteral nutrition, were analyzed for 2 months. Raw electronic data were retrieved and subjected to quality controls. Infusion combinations were classified as compatible, incompatible, no data, or variable according to the internal hospital charts, Trissel's database, and the Swiss summary of product characteristics. For situations with incompatible coadministrations, we assessed alternative distributions of infusions among the currently available lumen. RESULTS Data for 100 patients were analyzed. Patients were exposed to a mean of 6.9 ± 3.6 individual continuous infusions administered through 3.8 ± 1.8 lumina. Among the 1447 coadministered continuous infusions, we detected 146 incompatible combinations (10%), resulting in 105 individually relevant incompatible situations. Furthermore, 185 combinations (13%) were not covered by internal compatibility charts, and for 207 combinations (15%) no data on compatibility were available. We found that 58% of the incompatible situations could have been avoided by a redistribution of the infusions among the available lumina. CONCLUSIONS Most infusion combinations in the studied PICU/NICU were compatible and covered by the internal compatibility charts. However, we also identified concurrent administrations of incompatible infusions or for which compatibility data are not available. A significant reduction of coadministrations of incompatible infusions could be achieved through optimal use of available lumina.

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Types and frequency of errors in the preparation and administration of drugs

Cited by 65 publications

References 11 publications

Intensity of nursing work in public hospitals

Intensity of nursing work in public hospitals

European Databases on Stability and Compatibility of Injectable Medicinal Products in Europe

Evaluation of Incompatible Coadministration of Continuous Intravenous Infusions in a Pediatric/Neonatal Intensive Care Unit

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