Types, principle, and characteristics of tandem high-resolution mass spectrometry and its applications

Lin, Liwu; Lin, Hongmei; Zhang, Miao; Dong, Xiaoxv; Yin, Xingbin; Qu, Changhai; Ni, Jian

doi:10.1039/c5ra22856e

Cited by 30 publications

(20 citation statements)

References 119 publications

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“…Using HRMS or working in multiple reaction monitoring (MRM) mode can drastically decrease the background noise of a spectrum and will therefore have a positive influence on the signal-to-noise ratio which often leads to an increased sensitivity [28]. However, sensitivity remains particularly related to the improved formation and guidance of analyte ions [10,29].…”

Section: (B) Ionization Methodsmentioning

confidence: 99%

“…For the analysis of rather apolar/volatile compounds, ions are preferably produced by an APCI source as they can evaporate in the ESI spray without being charged [37]. Therefore, Waters (ESCi) and later also AB Sciex (IonDrive DuoSpray) came up with a multimode ionization source which can alternately switch between ESI and APCI to ionize every analyte in the sample [10,38,39]. This allows the successful analysis of both polar and apolar compounds.…”

Section: (B) Ionization Methodsmentioning

confidence: 99%

“…Very recently, Lin et al [10] published an overview of tandem high-resolution MS wherein they described how different manufacturers applied various techniques to augment the ion guidance from the source towards the analyser. These data are compiled in electronic supplementary material, table S1 to provide a comprehensive summary of the principal ion guidance mechanisms [10,21,45,46].…”

Section: (C) Ion Formation and Guidancementioning

confidence: 99%

“…A number of comprehensive reviews compare the advantages and disadvantages associated with the use of specific instruments and provide a clear overview that can be consulted before selecting an apparatus to perform specific experiments [2,[10][11][12]. To be clear, every mass spectrometer has its advantages and limitations and comparing different instruments is therefore difficult.…”

Section: Instrumental Advances (A) Mass Analyzersmentioning

confidence: 99%

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Quantitative mass spectrometry methods for pharmaceutical analysis

Loos¹,

Schepdael²,

Cabooter³

2016

Phil. Trans. R. Soc. A.

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Quantitative pharmaceutical analysis is nowadays frequently executed using mass spectrometry. Electrospray ionization coupled to a (hybrid) triple quadrupole mass spectrometer is generally used in combination with solid-phase extraction and liquid chromatography. Furthermore, isotopically labelled standards are often used to correct for ion suppression. The challenges in producing sensitive but reliable quantitative data depend on the instrumentation, sample preparation and hyphenated techniques. In this contribution, different approaches to enhance the ionization efficiencies using modified source geometries and improved ion guidance are provided. Furthermore, possibilities to minimize, assess and correct for matrix interferences caused by co-eluting substances are described. With the focus on pharmaceuticals in the environment and bioanalysis, different separation techniques, trends in liquid chromatography and sample preparation methods to minimize matrix effects and increase sensitivity are discussed. Although highly sensitive methods are generally aimed for to provide automated multi-residue analysis, (less sensitive) miniaturized set-ups have a great potential due to their ability for in-field usage. This article is part of the themed issue ‘Quantitative mass spectrometry’.

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Section: (B) Ionization Methodsmentioning

confidence: 99%

Section: (B) Ionization Methodsmentioning

confidence: 99%

Section: (C) Ion Formation and Guidancementioning

confidence: 99%

Section: Instrumental Advances (A) Mass Analyzersmentioning

confidence: 99%

See 2 more Smart Citations

Quantitative mass spectrometry methods for pharmaceutical analysis

Loos¹,

Schepdael²,

Cabooter³

2016

Phil. Trans. R. Soc. A.

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“…In recent decades, high resolution mass spectrometry had gained popularity due to its accurate mass measurement, which simplied the process of identication and the analysis time was thus shortened. 20,21 Therefore, in this study, an efficient and reliable ultra-high-performance liquid chromatography combined with electrospray ionization quadrupole time-of-ight tandem mass spectrometry (UHPLC/ ESI-Q-TOF-MS/MS) method was established to screen and identify the effective components in X. sorbifolia husks. Thousands of high resolution MS and MS/MS data was obtained during chemical proling.…”

Section: Introductionmentioning

confidence: 99%

A time-of-flight mass spectrometry based strategy to fast screen triterpenoids in Xanthoceras sorbifolia Bunge husks for bioactive substances against Alzheimer's disease

et al. 2018

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Xanthoceras sorbifolia Bunge is a folk medicine in China. Recently, the triterpenoids in its husks have attracted more and more attention for potential prevention against Alzheimer's disease. However, current studies on its bioactive substances were still insufficient. To reveal more bioactive substances, an efficient and practical strategy based on high resolution mass spectra coupled with multiple data mining techniques was developed to characterize the barrigenol type triterpenoids in the husks and dosed rat plasma. A total of 50 barrigenol type triterpenoids were identified in the husks, and 6 of these were detected in the rat plasma, which were regarded as bioactive candidates. To find the real bioactive substances, the neuroprotective effect of the candidates was further tested by calculating the PC12 cell viability against amyloid-b-induced cytotoxicity. As a result, three out of the six candidates exhibited obvious neuroprotction against amyloid-b-induced cytotoxicity on PC12 cells, indicating their potential to be bioactive substances against Alzheimer's disease. This study will be a valuable reference of the bioactive substances in Xanthoceras sorbifolia Bunge husks against Alzheimer's disease and the provided strategy can also be applied to the exploration of the effective constituents in other medicines.

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ChemInform Abstract: Types, Principle, and Characteristics of Tandem High‐Resolution Mass Spectrometry and Its Applications

Lin

Zhang

et al. 2016

ChemInform

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Types, principle, and characteristics of tandem high-resolution mass spectrometry and its applications

Abstract: We review the principle and functional characteristics of different types or models for THRMS and provide a brief description of its applications in medical research, food safety, and environmental protection fields.

Cited by 30 publications

References 119 publications

Quantitative mass spectrometry methods for pharmaceutical analysis

Quantitative mass spectrometry methods for pharmaceutical analysis

A time-of-flight mass spectrometry based strategy to fast screen triterpenoids in Xanthoceras sorbifolia Bunge husks for bioactive substances against Alzheimer's disease

ChemInform Abstract: Types, Principle, and Characteristics of Tandem High‐Resolution Mass Spectrometry and Its Applications

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