Typhoid conjugate vaccine: are we heading towards the elimination of typhoid in endemic countries?

XDR Salmonella typhi Warrants Vaccine Use in Asian Pacific Region: Prevention Is Still Better Than Cure

“…3 Furthermore, in a recent randomized control trial, the authors reported good immunogenicity and safety of TCV among Malawian children. 4 Thus, with the availability of these low cost, highly effective, and safe TCV, there is growing optimism regarding the elimination of typhoid fever in endemic regions. 3,4 In addition, it is imperative to promote widespread use of the vaccine due to the increasing incidence of extensively drug-resistant (XDR) Salmonella typhi, making available treatment less effective and costly.…”

“…4 Thus, with the availability of these low cost, highly effective, and safe TCV, there is growing optimism regarding the elimination of typhoid fever in endemic regions. 3,4 In addition, it is imperative to promote widespread use of the vaccine due to the increasing incidence of extensively drug-resistant (XDR) Salmonella typhi, making available treatment less effective and costly. Typhi isolates are defined as XDR, if they are multidrug resistant, nonsusceptible to fluoroquinolones, and resistant to third-generation cephalosporins, that is, ceftriaxone.…”

“…3 Furthermore, in a recent randomized control trial, the authors reported good immunogenicity and safety of TCV among Malawian children. 4 Thus, with the availability of these low cost, highly effective, and safe TCV, there is growing optimism regarding the elimination of typhoid fever in endemic regions. 3,4…”

“…4 Thus, with the availability of these low cost, highly effective, and safe TCV, there is growing optimism regarding the elimination of typhoid fever in endemic regions. 3,4…”