Typhoid Fever as a Rare Cause of Hepatic, Splenic, and Bone Marrow Granulomas

Mert, Ali; Tabak, Fehmı; Özaras, Reşat; Öztürk, Recep; Akı, Hilal; Aktuglu, Yildirim

doi:10.2169/internalmedicine.43.436

Cited by 40 publications

(26 citation statements)

References 15 publications

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“…In differential diagnosis with acute viral infections, the severity of jaundice and the extent of elevation of transaminase levels are much greater than those observed in typhoid fever. The cause of the increase in transaminases in typhoid fever may also be hepatic granulomas or hepatic abscesses formation (14). But in our case, there was no such a space-occupying lesion.…”

Section: Discussioncontrasting

confidence: 48%

A Case of Typhoid Fever Presenting With Multiple Complications

et al. 2007

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An 18-year old female patient was admitted to the Emergency Department with complaints of fever and fatigue beginning 15 days ago associated with headache, weakness, palpitation, abdominal pain, and diarrhea a week later. The patient who apathic confused and discordant was transferred to the Department of Infectious Diseases. There was also hypocalcemia, hypopotassemia, pancytopenia, intestinal hemorrhage, and hepatic involvement. S. typhi was grown in the blood culture. The patient was discharged with full recovery after ciprofloxacin treatment in addition to electrolyte replacement. Typhoid fever is a widespread infectious disease in our country and should be taken into consideration in differential diagnosis of many diseases because it may involve a number of systems and may present with a variety of complications.

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Section: Discussioncontrasting

confidence: 48%

A Case of Typhoid Fever Presenting With Multiple Complications

et al. 2007

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“…The patient improved rapidly with the treatment of typhoid fever. Mert et al [4] also reported a case with splenic granuloma and another case with bone marrow granuloma in addition to hepatic granuloma.…”

Section: Discussionmentioning

confidence: 96%

“…When it occurs, granulomas are described in sites other than the primary intestinal ulcer. Only 5 cases of typhoid fever with hepatic granulomas have been reported in the English language literature [2][3][4] . Paris [2] reported 5 cases of typhoid hepatitis, out of which 2 revealed hepatic granulomas.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous Inflammatory Response in a Case of Typhoid Fever

Bharadwaj

Anim²,

Ebrahim³

et al. 2009

Med Princ Pract

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Objective: To present a case of culture-proven typhoid fever in which granulomas were demonstrated histologically in the ileum and mesenteric lymph nodes. Clinical Presentation and Intervention: A 47-year-old Pakistani man underwent emergency hemicolectomy for severe bleeding per rectum associated with diarrhea. Two large ulcers in the ileum, near the ileocolic junction, as well as mesenteric lymph nodes showed both necrotizing and non-necrotizing granulomas in addition to mixed inflammatory infiltrate on histology. Conclusion: Typhoid fever may be considered as one of the causes of the differential diagnoses of granulomatous inflammation of the small intestine.

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“…Re ports of granulomas in the liver, bone marrow and spleen with typhoid fever have been published previously. 8 An account of cutaneous granulomata associated with the typhoid -paratyphoid heat-killed vaccine has also been reported. 9 Previously reported histopathologic findings associated with typhoid enteritis include hypertrophy of the ileal mucosa and neutrophil-poor, monocyte/ macrophage-rich mucosal infiltrates.…”

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confidence: 99%