Typical and atypical symptoms of gastro esophageal reflux disease: Does<i>Helicobacter pylori</i>infection matter?

Grossi, Laurino; Ciccaglione, Antonio Francesco; Marzio, L.

doi:10.4292/wjgpt.v6.i4.238

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…Typical/reflux (R) symptoms were defined as heartburn and regurgitation. Atypical/airway (A) symptoms were defined as cough, asthma, hoarseness, and/or chest pain 6 7 8 . Symptom groups were classified as R only, A only, and R + A.…”

Section: Methodsmentioning

confidence: 99%

Real-world prevalence of endoscopic findings in patients with gastroesophageal reflux symptoms: a cross-sectional study

et al. 2022

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Background and study aims Data regarding endoscopic findings and symptom correlation in patients with gastroesophageal reflux disease (GERD) symptoms are largely limited to single-center experiences. We performed a nationwide study to examine the association between patient-reported GERD symptoms and clinically relevant endoscopic findings. Patients and methods Using the National Endoscopic Database, we retrospectively identified all esophagogastroduodenoscopies (EGDs) performed for GERD symptoms from 2000 to 2014. Patients were categorized into three symptom groups: 1) typical reflux only (R); 2) airway only (A); and 3) both R and A (R + A). Outcomes were the point prevalence of endoscopic findings in relation to patient-reported GERD symptom groups. Statistical analyses were performed using R. Results A total of 167,459 EGDs were included: 96.8 % for R symptoms, 1.4 % for A symptoms, and 1.8 % for R + A symptoms. Of the patients, 13.4 % had reflux esophagitis (RE), 9.0 % Barrett’s esophagus (BE), and 45.4 % hiatal hernia (HH). The R + A group had a significantly higher point prevalence of RE (21.6 % vs. 13.3 % and 12 %; P < 0.005) and HH (56.9 % vs. 45.3 % and 38.3 %; P < 0.005) compared to the R or A groups, respectively. The R group had a significantly higher point prevalence of BE compared to the A or R + A groups, respectively (9.1 % vs. 6.1 % and 6.1 %, P < 0.005). Conclusions On a national level, patients experiencing R + A GERD symptoms appear more likely to have RE and HH, while those with only R symptoms appear more likely to have BE. These real-world data may help guide how providers and institutions approach acid-suppression therapy, set thresholds for recommending EGD, and develop management algorithms.

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Section: Methodsmentioning

confidence: 99%

Real-world prevalence of endoscopic findings in patients with gastroesophageal reflux symptoms: a cross-sectional study

et al. 2022

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Helicobacter pylori and Gallstone Disease: Incidence and Outcomes in a Los Angeles County Population

Kapadia

Kaji

Hari

et al. 2021

Journal of Gastrointestinal Surgery

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Anxiety and depression in patients with gastroesophageal reflux disorder

Javadi

Shafikhani

2017

Electron Physician

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BackgroundEvidence shows an influence relationship between described symptoms of gastroesophageal reflux disorder (GERD) and emotional state.ObjectiveTo determine the relationship between anxiety and depression with GERD in patients referred to the endoscopy unit of Bouali-Sina Hospital in Qazvin.MethodsThis case-control study was conducted in the endoscopy unit of Bouali-Sina Hospital in Qazvin, Iran, from April 2014 through May 2015. Two hundred individuals (100 patients with GERD and 100 healthy individuals as a control group) were enrolled into the current study. All subjects completed the hospital anxiety and depression questionnaire. GERD was diagnosed based on the Los Angeles classification system. Demographic and socioeconomic characteristics in addition to clinical history of subjects were collected and analyzed using proper statistical methods (independent-samples t-test and AVOVA) and using SPSS version 22.ResultsAmong the recruited patients, 50 subjects had erosive esophagitis (ERD) and 50 had non-erosive esophagitis (NERD). The anxiety score was significantly higher in the NERD group than the ERD and control groups (p=0.017; p<0.001). In addition, the anxiety score was significantly higher in the ERD group than the control group (p=0.014). The score of depression was higher in the NERD group than the ERD and the control groups. However, this difference was not statistically significant for the ERD group (p=0.63), but the difference was significant in comparison to the control group (p<0.001). There was no significant difference among the groups regarding age, gender or body mass index (BMI). The number of smokers was significantly higher in the ERD group than the NERD and control groups (p<0.001).ConclusionThe current study showed that mental factors (anxiety and depression) play important roles in the development of GERD, especially NERD; therefore, it is recommended to consider these factors to select a suitable treatment plan.

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Typical and atypical symptoms of gastro esophageal reflux disease: DoesHelicobacter pyloriinfection matter?

Cited by 3 publications

References 29 publications

Real-world prevalence of endoscopic findings in patients with gastroesophageal reflux symptoms: a cross-sectional study

Real-world prevalence of endoscopic findings in patients with gastroesophageal reflux symptoms: a cross-sectional study

Helicobacter pylori and Gallstone Disease: Incidence and Outcomes in a Los Angeles County Population

Anxiety and depression in patients with gastroesophageal reflux disorder

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