Typical Azole Biocides in Biosolid-Amended Soils and Plants Following Biosolid Applications

Chen, Zhifeng; Ying, Guang‐Guo; Ma, Yibing; Lai, Hua‐Jie; Chen, Feng; Pan, Chang-Gui

doi:10.1021/jf4013949

Cited by 28 publications

(15 citation statements)

References 39 publications

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“…Human-use azoles such as voriconazole, isavuconazole, and posaconazole are used to treat invasive forms of aspergillosis and other severe fungal infections [11]. Other azole drugs such as climbazole and clotrimazole are used to treat topical fungal infections [13]. Azole fungicides like tebuconazole and propiconazole are used against a variety of plant pathogenic fungi causing diseases such as powdery mildew, downy mildew, rusts, leaf spots, and flower blights [14].…”

Section: Aspergillus Fumigatusmentioning

confidence: 99%

Azole-resistant Aspergillus fumigatus in the environment: Identifying key reservoirs and hotspots of antifungal resistance

et al. 2021

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Aspergillus fumigatus is an opportunistic human pathogen that causes aspergillosis, a spectrum of environmentally acquired respiratory illnesses. It has a cosmopolitan distribution and exists in the environment as a saprotroph on decaying plant matter. Azoles, which target Cyp51A in the ergosterol synthesis pathway, are the primary class of drugs used to treat aspergillosis. Azoles are also used to combat plant pathogenic fungi. Recently, an increasing number of azole-naive patients have presented with pan-azole–resistant strains of A. fumigatus. The TR34/L98H and TR46/Y121F/T289A alleles in the cyp51A gene are the most common ones conferring pan-azole resistance. There is evidence that these mutations arose in agricultural settings; therefore, numerous studies have been conducted to identify azole resistance in environmental A. fumigatus and to determine where resistance is developing in the environment. Here, we summarize the global occurrence of azole-resistant A. fumigatus in the environment based on available literature. Additionally, we have created an interactive world map showing where resistant isolates have been detected and include information on the specific alleles identified, environmental settings, and azole fungicide use. Azole-resistant A. fumigatus has been found on every continent, except for Antarctica, with the highest number of reports from Europe. Developed environments, specifically hospitals and gardens, were the most common settings where azole-resistant A. fumigatus was detected, followed by soils sampled from agricultural settings. The TR34/L98H resistance allele was the most common in all regions except South America where the TR46/Y121F/T289A allele was the most common. A major consideration in interpreting this survey of the literature is sampling bias; regions and environments that have been extensively sampled are more likely to show greater azole resistance even though resistance could be more prevalent in areas that are under-sampled or not sampled at all. Increased surveillance to pinpoint reservoirs, as well as antifungal stewardship, is needed to preserve this class of antifungals for crop protection and human health.

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Section: Aspergillus Fumigatusmentioning

confidence: 99%

Azole-resistant Aspergillus fumigatus in the environment: Identifying key reservoirs and hotspots of antifungal resistance

et al. 2021

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“…Particularly, the highly prescribed, low-polar drugs clotrimazole (CTZ), ketoconazole (KTZ) and miconazole (MCZ) might reach relevant concentrations, up to 1000 ng g −1 , in sludge of STPs [10,11,[13][14][15][16]. From sludge, they can be incorporated into agricultural soils as part of fertiliser preparations [17,18]. When present in soil, the UV components of solar radiation might contribute to partial degradation, or even complete mineralization, of the fraction of these pollutants in the upper soil layer.…”

Section: Introductionmentioning

confidence: 99%

Identification of antimycotic drugs transformation products upon UV exposure

Casado

Rodrı́guez

Ramil

et al. 2015

Journal of Hazardous Materials

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“…Fungicides are also entrained into soil through the application of biosolids (Chen et al, 2013).…”

Section: Antibiotic Resistance Genes In Soilmentioning

confidence: 99%

Antibiotic Resistance Genes in the Human-Impacted Environment: A One Health Perspective

et al. 2019

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Antibiotic resistance and its environmental component is gaining more attention as part of combating the growing healthcare crisis. The One-Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture and the environment are the core and interrelated components. This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely urban wastewater treatment plants, aquaculture production systems, soil receiving manures and biosolids and the atmosphere which includes longer range dispersal. Much recent work has been done describing antibiotic resistance genes in various environments; now quantitative, mechanistic and hypothesis driven studies are needed to identify practices that reduce real risk and maintain effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed to provide the surveillance information to identify risk and define barriers that can reduce risk. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistances, as well as practices that limit dispersal or destroy antibiotic resistant bacteria or their resistance genes that are feasible for these varied environmental domains.

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Typical Azole Biocides in Biosolid-Amended Soils and Plants Following Biosolid Applications

Cited by 28 publications

References 39 publications

Azole-resistant Aspergillus fumigatus in the environment: Identifying key reservoirs and hotspots of antifungal resistance

Azole-resistant Aspergillus fumigatus in the environment: Identifying key reservoirs and hotspots of antifungal resistance

Identification of antimycotic drugs transformation products upon UV exposure

Antibiotic Resistance Genes in the Human-Impacted Environment: A One Health Perspective

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