We study quantum bipartite systems in a random pure state, where von Neumann entropy is considered as a measure of the entanglement. Expressions of the first and second exact cumulants of von Neumann entropy, relevant respectively to the average and fluctuation behavior, are known in the literature. The focus of this paper is on its skewness that specifies the degree of asymmetry of the distribution. Computing the skewness requires additionally the third cumulant, an exact formula of which is the main result of this work. In proving the main result, we obtain as a byproduct various summation identities involving polygamma and related functions. The derived third cumulant also leads to an improved approximation to the distribution of von Neumann entropy.