Tyramine and Octopamine Receptors as a Source of Biorational Insecticides

Hirashima, Akinori

doi:10.1007/978-90-481-2316-2_4

Cited by 3 publications

(1 citation statement)

References 95 publications

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“…Epinephrine and norepinephrine are natural non‐selective agonists of α ‐ and β ‐adrenergic receptors in mammals, but they do not have a known physiological role in insects . Because insect and vertebrate systems are analogous, there have been reports of non‐selectivity between invertebrate and vertebrate‐targeted ligands; however, as there are differences between insect OA and TA signaling and mammalian adrenergic systems, it has been suggested that there may be potential for developing selective insecticides . Therefore, known adrenergic receptor ligands were identified as a potential starting point for novel insecticides because of the aforementioned attractive properties, including involvement in a variety of important physiological functions in insects, validated commercial‐level activity and the potential for insect selectivity.…”

Section: Introductionmentioning

confidence: 99%

Pro‐insecticidal approach towards increasing in planta activity

Creemer¹,

Giampietro²,

Lambert³

et al. 2016

Pest Management Science

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Adrenergic active compounds, such as clonidine analogs, show potential as insecticides; however, a designed prodrug approach did not overcome the lack of translation in this case. Studies confirmed that the synthesized prodrug analog metabolized in planta to the proposed vacuole-trapped compound. One possible explanation for the failure of this approach is that the rate of metabolism and vacuole trapping is faster than translaminar flow, and therefore the released pesticide is not biologically available to the target organism. © 2016 Society of Chemical Industry.

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Section: Introductionmentioning

confidence: 99%

Pro‐insecticidal approach towards increasing in planta activity

Creemer¹,

Giampietro²,

Lambert³

et al. 2016

Pest Management Science

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A Review of Aminothiazoline Chemistry

Wedel

Deyn

Soergel

et al. 2017

ACS Symposium Series

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Neuroactive Insecticides: Targets, Selectivity, Resistance, and Secondary Effects

Casida

Durkin

2013

Annu. Rev. Entomol.

672

405

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Neuroactive insecticides are the principal means of protecting crops, people, livestock, and pets from pest insect attack and disease transmission. Currently, the four major nerve targets are acetylcholinesterase for organophosphates and methylcarbamates, the nicotinic acetylcholine receptor for neonicotinoids, the γ-aminobutyric acid receptor/chloride channel for polychlorocyclohexanes and fiproles, and the voltage-gated sodium channel for pyrethroids and dichlorodiphenyltrichloroethane. Species selectivity and acquired resistance are attributable in part to structural differences in binding subsites, receptor subunit interfaces, or transmembrane regions. Additional targets are sites in the sodium channel (indoxacarb and metaflumizone), the glutamate-gated chloride channel (avermectins), the octopamine receptor (amitraz metabolite), and the calcium-activated calcium channel (diamides). Secondary toxic effects in mammals from off-target serine hydrolase inhibition include organophosphate-induced delayed neuropathy and disruption of the cannabinoid system. Possible associations between pesticides and Parkinson's and Alzheimer's diseases are proposed but not established based on epidemiological observations and mechanistic considerations.

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Tyramine and Octopamine Receptors as a Source of Biorational Insecticides

Cited by 3 publications

References 95 publications

Pro‐insecticidal approach towards increasing in planta activity

Pro‐insecticidal approach towards increasing in planta activity

A Review of Aminothiazoline Chemistry

Neuroactive Insecticides: Targets, Selectivity, Resistance, and Secondary Effects

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