Tyramine in foods and monoamine oxidase inhibitor drugs: A crossroad where medicine, nutrition, pharmacy, and food industry converge

McCabe‐Sellers, Beverly; Staggs, C.G.; Bogle, Margaret L.

doi:10.1016/j.jfca.2005.12.008

Cited by 154 publications

(99 citation statements)

References 88 publications

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“…The examination of amines concentration in food is particularly interesting because they can be used as biosensors (McCabe-Sellers et al 2006;Roig 2002). It is very important to obtain as much data as possible in one analysis, which means simultaneous determination of compounds from more than one group and opportunity to use one procedure for several different food products.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Biogenic Amines and Methylxanthines in Foodstuff—Sample Preparation with HPLC-DAD-FL Analysis

Baranowska

Płonka

2014

Food Anal. Methods

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Chromatographic system for simultaneous determination of levodopa, biogenic amines, and methylxanthines in food has been developed. Chromatographic column and precolumn with octadecylsilane phase and simultaneously fluorescence and DAD detectors have been used. Gradient elution with acetate buffer (pH=4.66) with acetonitrile has been applied. Examination included levodopa, norepinephrine, dopamine, normetanephrine, tyramine, and serotonin as well as caffeine, theophylline, and theobromine. Limit of detection (LOD) and limit of quantitation (LOQ) have been determined for all compounds with signal to noise ratio (S/N) equal to 3 and 10, respectively. LOD of 10 ng/mL and LOQ of 30 ng/mL for levodopa and biogenic amines as well as LOD of 70 (60) ng/mL and LOQ of 210 (180)ng/mL for methylxanthines have been determined. Authors have also developed method for simultaneous separation of all analytes from food matrix. Developed chromatographic system with sample preparation method has been applied for determination of examined compounds in cocoa products, vegetables, and fruits.

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Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Biogenic Amines and Methylxanthines in Foodstuff—Sample Preparation with HPLC-DAD-FL Analysis

Baranowska

Płonka

2014

Food Anal. Methods

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“…Since it is a potent vasoconstrictor, tyramine can induce hypertension, migraines, brain hemorrhage, and heart failure when high concentrations are present in an organism (17,26). Tyramine is broken down in mammals by monoamine oxidase (MAO)-catalyzed oxidative deimination (18). However, the detoxifying mechanisms in humans are not sufficient when the intake in a diet is too high, when individuals are allergic, and when patients consume drugs that act on MAO inhibitors (anti-Parkinson disease drugs and antidepressants that inhibit MAO) (24,26).…”

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confidence: 99%

Dual Role for the Tyrosine Decarboxylation Pathway inEnterococcus faeciumE17: Response to an Acid Challenge and Generation of a Proton Motive Force

Pereira

Matos

Romão

et al. 2009

Appl Environ Microbiol

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In this work we investigated the role of the tyrosine decarboxylation pathway in the response of Enterococcus faecium E17 cells to an acid challenge. It was found that 91% of the cells were able to remain viable in the presence of tyrosine when they were incubated for 3 h in a complex medium at pH 2.5. This effect was shown to be related to the tyrosine decarboxylation pathway. Therefore, the role of tyrosine decarboxylation in pH homeostasis was studied. The membrane potential and pH gradient, the parameters that compose the proton motive force (PMF), were measured at different pHs (pH 4.5 to 7). We obtained evidence showing that the tyrosine decarboxylation pathway generates a PMF composed of a pH gradient formed due to proton consumption in the decarboxylation reaction and by a membrane potential which results from electrogenic transport of tyrosine in exchange for the corresponding biogenic amine tyramine. The properties of the tyrosine transporter were also studied in this work by using whole cells and right-side-out vesicles. The results showed that the transporter catalyzes homologous tyrosine/tyrosine antiport, as well as electrogenic heterologous tyrosine-tyramine exchange. The tyrosine transporter had properties of a typical precursor-product exchanger operating in a proton motive decarboxylation pathway. Therefore, the tyrosine decarboxylation pathway contributes to an acid response mechanism in E. faecium E17. This decarboxylation pathway gives the strain a competitive advantage in nutrient-depleted conditions, as well as in harsh acidic environments, and a better chance of survival, which contributes to higher cell counts in food fermentation products.

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“…In reality most foods can be safely consumed if bought fresh and immediately cooked and consumed in modest quantities. 14 Over time, as food degenerates or is stored incorrectly, the biogenic amine content, including tyramine, increases. 14 Table 3 highlights the dietary restrictions associated with MAOIs.…”

Section: Significant Pharmacodynamic Interactionsmentioning

confidence: 99%

“…14 Over time, as food degenerates or is stored incorrectly, the biogenic amine content, including tyramine, increases. 14 Table 3 highlights the dietary restrictions associated with MAOIs. The reversible mon oamine oxidase inhibitor, moclobemide, incurs a much lower risk of dietary interactions because it is displaced by circulating noradrenaline enabling the MAO A to retain some function.…”

Section: Significant Pharmacodynamic Interactionsmentioning

confidence: 99%

Antidepressant drug interactions: evidence and clinical significance

Bleakley¹

2016

Prog. Neurol. Psychiatry

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Antidepressants are widely used in the general population, primarily to treat depression but also commonly in conditions such as anxiety disorders and neuropathic pain. This article considers the significant pharmacodynamic and pharmacokinetic drug interactions of different antidepressants, whilst remembering that individual patient characteristics are of utmost importance in the prescribing decision.

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Tyramine in foods and monoamine oxidase inhibitor drugs: A crossroad where medicine, nutrition, pharmacy, and food industry converge

Cited by 154 publications

References 88 publications

Simultaneous Determination of Biogenic Amines and Methylxanthines in Foodstuff—Sample Preparation with HPLC-DAD-FL Analysis

Simultaneous Determination of Biogenic Amines and Methylxanthines in Foodstuff—Sample Preparation with HPLC-DAD-FL Analysis

Dual Role for the Tyrosine Decarboxylation Pathway inEnterococcus faeciumE17: Response to an Acid Challenge and Generation of a Proton Motive Force

Antidepressant drug interactions: evidence and clinical significance

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