Tyrosinase inhibitory peptides: Structure-activity relationship study on peptide chemical properties, terminal preferences and intracellular regulation of melanogenesis signaling pathways

Employing fruit juices to hydrolyze edible bird's nest and enhance the antioxidant, anti-tyrosinase, and wound-healing activities of the hydrolysates

“…On the other hand, the potency to inhibit tyrosinase activity of the cantaloupe juice-treated hydrolysate is similar to that of the bromelain-treated one despite the fact that cantaloupe juice generated a lower DH value than bromelain. The differences in the anti-tyrosinase activity of EBN hydrolysates might be caused by the levels of free sialic acid or the properties of bioactive peptides (hydrophobicity, amino acid type, and the arrangement of terminal amino acid residues) in the hydrolysates [ 48 ].…”

Malignant Melanoma: An Overview, New Perspectives, and Vitamin D Signaling

“…Thus, inhibition of melanogenesis represents a realistic adjuvant strategy to amplify existing therapeutic approaches ( Figure 1 ) [ 4 , 235 , 367 , 393 ]. In this context, it is worth mentioning that a diverse range of non-toxic inhibitors of tyrosinase activity are available [ 292 , 394 , 395 , 396 ], which in addition to copper chelators (cofactor for tyrosinase) would inhibit tyrosinase and decrease melanin synthesis [ 365 , 367 , 371 , 373 , 397 , 398 , 399 , 400 ]. However, we acknowledge that others, including some of us, have proposed using the melanogenic pathway as a tool for melanoma therapy utilizing the cytotoxicity of melanogenesis products [ 248 , 377 , 380 , 401 , 402 ], also reviewed in [ 4 ].…”