2000
DOI: 10.1006/cyto.1999.0531
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TYROSINE 462 OF THE MEMBRANE-PROXIMAL F′-G′ LOOP OF MURINE Mpl IS NOT ESSENTIAL FOR HIGH-AFFINITY BINDING OF THROMBOPOIETIN

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Cited by 9 publications
(10 citation statements)
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“…1 and 2). This result is in keeping with the findings of several other independent approaches in the literature (33)(34)(35). It is also consistent with the fact that the Mpl-EC-D2 is not involved in ligand binding but is instead needed for receptor activation (36).…”
Section: Discussionsupporting
confidence: 92%
“…1 and 2). This result is in keeping with the findings of several other independent approaches in the literature (33)(34)(35). It is also consistent with the fact that the Mpl-EC-D2 is not involved in ligand binding but is instead needed for receptor activation (36).…”
Section: Discussionsupporting
confidence: 92%
“…Recent studies demonstrate that the membranedistal, but not the membrane-proximal, CRH domain of c-Mpl is a receptor domain for TPO. Binding of radioactively labeled TPO to BaF3 cells expressing mutants of murine c-Mpl was abolished when the distal CRH domain was either deleted or replaced with a second copy of the proximal CRH domain (51). These studies also showed that BaF3 cells expressing these c-Mpl mutants grew constitutively even in the absence of TPO, indicating that the membrane distal CRH domain also functions to inhibit autophosphorylation in the absence of TPO.…”
Section: Implications For the Mechanism Of Signal Transduction By C-mplmentioning
confidence: 76%
“…IL-2R␣ cDNA (untagged) and human wild-type or JAK3 A572V mutant cDNAs were subcloned in pREX-IRES-CD4 (34). FLAG-tagged murine thrombopoietin receptor (TpoR) containing the IL-7R signal sequence (35) was cloned in pMX-IRES-GFP1.1 (30). Myc-tagged type II transforming growth factor-␤ (T␤RII) in pcDNA3 was described (36).…”
Section: Methodsmentioning
confidence: 99%