Tyrosine: A Possible Marker of Severe Intestinal Injury During Ischemia

Contrin, Lígia Márcia; Lobo, Suzana M.; Navegantes, Luiz Carlos Carvalho; Orrico, Suzana Perez; Queiroz, Marcio M; Cury, Patrí­cia Maluf; Lira, Eduardo Carvalho; Carta, Adriana; Yamamoto, A; Vincent, Jean‐Louis

doi:10.1016/j.jss.2008.06.018

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Most of these studies have focused on potential biological markers of gut ischemia and injury, including measuring various intracellular enzymes released by the ischemic bowel, such as aminotransferase, LDH, D(-)-lactate, tyrosin, creatine phosphokinase and alcohol dehydrogenase (10)(11)(12)(13)(14). Unfortunately, all these markers have a low specificity and can not be used in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Analysis of serum enzyme levels in a rabbit model of acute mesenteric ischemia

Zhang

2011

Mol Med Report

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Abstract. Early diagnosis of acute mesenteric ischemia (AMI) remains very difficult, partly due to the fact that useful markers of early small bowel ischemia have not yet been identified. Thus, in this study, we aimed to evaluate the levels of serum intracellular enzymes in the tissues and organs in a controlled animal model of mesenteric intestinal ischemia. Forty-eight New Zealand rabbits were divided into 4 groups including the control, artery ligation, vein ligation, and both artery and vein ligation groups. Plasma samples were obtained at 0-, 1-, 3-, 6-and 9-h time-points and enzyme levels were determined. The bowel color and vitality were observed at the same time. The bowel showed an appearance of infarction after a period of ischemia in the animals. Six and 9 h after superior mesenteric artery ischemia, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels increased significantly. However, after 3 h of superior mesenteric venous (SMV) ligation, γ-glutamyl transpeptidase levels in the blood were considerably higher compared to the control group. Six hours after SMV ischemia, ALT, AST, alkaline phosphatase and lactate dehydrogenase levels were significantly elevated compared to those pre-ligation. Serum enzyme levels during intestinal ischemia are not able to provide sufficient information as regards the extent and reversibility of intestinal ischemia, although, they may be able to reflect the presence of injury.

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Section: Discussionmentioning

confidence: 99%

Analysis of serum enzyme levels in a rabbit model of acute mesenteric ischemia

Zhang

2011

Mol Med Report

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Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy

et al. 2012

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Our results provide evidence for the renoprotective action of febuxostat against the formation of interstitial fibrosis. A decrease in macrophage infiltration and interstitial fibrosis, along with a decrease of the oxidative stress marker, strongly suggests the existence of a causal relationship between them. Febuxostat may have therapeutic value in slowing or preventing interstitial fibrosis in patients with CKD.

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Tyrosine: A Possible Marker of Severe Intestinal Injury During Ischemia

Cited by 2 publications

References 25 publications

Analysis of serum enzyme levels in a rabbit model of acute mesenteric ischemia

Analysis of serum enzyme levels in a rabbit model of acute mesenteric ischemia

Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy

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