Tyrosine carbon dots inhibit fibrillation and toxicity of the human islet amyloid polypeptide

Bloch, Daniel Nir; Zichri, Shani Ben; Kolusheva, Sofiya; Jelinek, Raz

doi:10.1039/d0na00870b

Cited by 13 publications

(11 citation statements)

References 55 publications

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“…This "structural memory" has been previously employed for modulating the surface properties of C-dots and targeting of the particles towards varied biological and chemical species. 14,[16][17][18] C-dots have been used in a wide range of applications such as bioimaging, 16,19,20 chemical and biological sensing, [21][22][23] catalysis, 24,25 and others. 26 Here, we demonstrate that C-dots prepared from lysine as the carbonaceous precursor interact with DOPAL, consequently inhibiting the adverse biological effects of the aldehyde.…”

Section: Introductionmentioning

confidence: 99%

“…9 In this context, scavengers of catabolic reactive aldehydes have been studied, including small molecules such as metformin. 10,11 Carbon dots (C-dots) are carbon-based nanoparticles exhibiting interesting physicochemical properties, including broad spectral uorescence, 12 low cytotoxicity, 13,14 and biocompatibility. 15 An important feature of C-dots is the retaining of functional residues originating from the molecular building blocks on their surface due to the mild synthesis conditions, especially low reaction temperatures.…”

Section: Introductionmentioning

confidence: 99%

“…This “structural memory” has been previously employed for modulating the surface properties of C-dots and targeting of the particles towards varied biological and chemical species. 14,16–18 C-dots have been used in a wide range of applications such as bioimaging, 16,19,20 chemical and biological sensing, 21–23 catalysis, 24,25 and others. 26…”

Section: Introductionmentioning

confidence: 99%

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Scavenging neurotoxic aldehydes using lysine carbon dots

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Scavenging neurotoxic aldehydes using lysine carbon dots

et al. 2023

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“…Self-assembled peptides − can serve as good candidates for fabricating functional coatings. − We have previously shown that the tripeptide L-3,4-dihydroxyphenylalanine (DOPA)-Phe(4F)-Phe(4F)-OMe can self-assemble into a coating that prevents the adhesion of proteins and bacteria on surfaces . In addition, we have recently reported that this peptide self-assembles in an aqueous solution into spherical particles …”

Section: Introductionmentioning

confidence: 99%

Antiviral Activity of Peptide-Based Assemblies

Agazani

Nir

et al. 2021

ACS Appl. Mater. Interfaces

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The COVID-19 pandemic highlighted the importance of developing surfaces and coatings with antiviral activity. Here, we present, for the first time, peptide-based assemblies that can kill viruses. The minimal inhibitory concentration (MIC) of the assemblies is in the range tens of micrograms per milliliter. This value is 2 orders of magnitude smaller than the MIC of metal nanoparticles. When applied on a surface, by drop casting, the peptide spherical assemblies adhere to the surface and form an antiviral coating against both RNA-and DNA-based viruses including coronavirus. Our results show that the coating reduced the number of T4 bacteriophages (DNA-based virus) by 3 log, compared with an untreated surface and 6 log, when compared with a stock solution. Importantly, we showed that this coating completely inactivated canine coronavirus (RNA-based virus). This peptide-based coating can be useful wherever sterile surfaces are needed to reduce the risk of viral transmission.

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“…Other factors, such as surface modification and size effect, play a critical role, but their influence on hIAPP fibrillation inhibition is not directly known. In the case of amino acid tyrosine-derived CQDs, the pronounced inhibitory effect is related to the display of ubiquitous aromatic residues on the CQDs’s surface, mimicking the antifibril and antitoxic activity of natural polyphenolic compounds. Amphiphilic CQDs, as proposed by the group of Leblanc, inhibited the overexpression of hIAPP and Aβ42 .…”

Section: Potential Of Carbon Nanoparticles and Carbon Colloids To Inh...mentioning

confidence: 99%

Nanoparticles and Nanocolloidal Carbon: Will They Be the Next Antidiabetic Class That Targets Fibrillation and Aggregation of Human Islet Amyloid Polypeptide in Type 2 Diabetes?

2022

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Conspectus Nanotechnology is revolutionizing human medicine. Nanoparticles (NPs) are currently used for treating various cancers, for developing vaccines, and for imaging, and other promises offered by NPs might come true soon. Due to the interplay between NPs and proteins, there is more and more evidence supporting the role of NPs for treating amyloid-based diseases. NPs can induce some conformational changes of the adsorbed protein molecules via various molecular interactions, leading to inhibition of aggregation and fibrillation of several and different amyloid proteins. Though an in depth understanding of such interactions between NPs and amyloid structures is still lacking, the inhibition of protein aggregation by NPs represents a new generation of innovative and effective medicines to combat metabolic diseases such as type 2 diabetes (T2D). Here, we lay out advances made in the field of T2D notably for optimizing protein aggregation inhibition strategies. This Account covers discussions about the current understanding of β-cells, the insulin producing cells within the pancreas, under diabetic conditions, notably increased glucose and fatty acid levels, and the implication of these conditions on the formation of human islet amyloid polypeptide (hIAPP) amylin oligomers and aggregates. Owing to the great potential of carbon nanostructures to interfere with protein aggregation, an important part of this Account will be devoted to the state of the art of therapeutic options in the form of emerging nanomaterials-based amyloidosis inhibitors. Our group has recently made some substantial progress in this regard by investigating the impact of glucose and fatty acid concentrations on hIAPP aggregation and β-cell toxicity. Furthermore, the great potential of carbon nanocolloids in reversing hIAPP aggregation under diabetic conditions will be highlighted as the approach has been validated on β-cell cultures from rats. We hope that this Account will evoke new ideas and concepts in this regard. We give some lead references below on pancreatic β-cell aspects and carbon quantum dots for managing diabetics and nanomedicine related aspects, a topic of interest in our laboratory.

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Tyrosine carbon dots inhibit fibrillation and toxicity of the human islet amyloid polypeptide

Abstract: Carbon dots prepared from tyrosine and citric acid inhibit fibrillation, membrane interactions and toxicity of hIAPP.

Cited by 13 publications

References 55 publications

Scavenging neurotoxic aldehydes using lysine carbon dots

Scavenging neurotoxic aldehydes using lysine carbon dots

Antiviral Activity of Peptide-Based Assemblies

Nanoparticles and Nanocolloidal Carbon: Will They Be the Next Antidiabetic Class That Targets Fibrillation and Aggregation of Human Islet Amyloid Polypeptide in Type 2 Diabetes?

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