Tyrosine kinase B receptor and BDNF expression in ovarian cancers – Effect on cell migration, angiogenesis and clinical outcome

Au, Christy; Siu, Michelle K.Y.; Liao, Xiaoyun; Wong, Eric T.T.; Ngan, Hextan Y.S.; Tam, Kwok-kan; Chan, Dominic C.W.; Chan, Queeny K.Y.; Cheung, Annie N.Y.

doi:10.1016/j.canlet.2009.02.025

Cited by 117 publications

(116 citation statements)

References 38 publications

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“…The RT-PCR results showed that the TGW neuroblastoma cell line expressed all domains of TrkB, as reported previously (17). The PCR products of this cell line were used as positive controls because the sequences of these products were consistent with the sequences of the TrkB domains in normal neural tissue registered in the NCBI database (NM006180.…”

Section: Resultssupporting

confidence: 80%

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Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma

Goto

Kametani

Kikugawa

et al. 2014

BST

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Section: Resultssupporting

confidence: 80%

“…To date, the over-expression of TrkB protein in cancers has been evaluated by immunohistochemical analysis (17). However, any major abnormalities of the molecular structure of TrkB have not been reported in cancer tissues.…”

Section: Introductionmentioning

confidence: 99%

Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma

Goto

Kametani

Kikugawa

et al. 2014

BST

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“…GDNF may play a role in the aetiology of ovarian cancer, as its expression was initially low in Fshr knockout mice, but in ageing females, which displayed an increase in the incidence of ovarian tumours, GDNF levels were up-regulated (Aravindakshan et al 2006). By contrast, BDNF is similarly expressed in normal and cancer cell lines and tissues (Au et al 2009). However, NTRK2 was reported to be overexpressed in ovarian cancers compared to either benign tumours or normal ovarian epithelium (Yu et al 2008, Au et al 2009, and its overexpression has been linked with poor prognosis in ovarian cancer patients (Au et al 2009).…”

Section: Potential Clinical Significancementioning

confidence: 99%

“…By contrast, BDNF is similarly expressed in normal and cancer cell lines and tissues (Au et al 2009). However, NTRK2 was reported to be overexpressed in ovarian cancers compared to either benign tumours or normal ovarian epithelium (Yu et al 2008, Au et al 2009, and its overexpression has been linked with poor prognosis in ovarian cancer patients (Au et al 2009). It is therefore possible that BDNF/NTRK2-mediated signalling, coupled with crosstalk from other pathways, may be associated with tumour metastasis and chemotherapeutic resistance in ovarian cancer, making NTRK2 a putative therapeutic target (reviewed in Siu et al (2009)).…”

Section: Potential Clinical Significancementioning

confidence: 99%

The roles of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor and nerve growth factor during the final stage of folliculogenesis: a focus on oocyte maturation

Linher‐Melville¹,

Li²

2013

Reproduction

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Neurotrophic factors were first identified to promote the growth, survival or differentiation of neurons and have also been associated with the early stages of ovarian folliculogenesis. More recently, their effects on the final stage of follicular development, including oocyte maturation and early embryonic development, have been reported. Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are expressed in numerous peripheral tissues outside of the CNS, most notably the ovary, are now known to stimulate oocyte maturation in various species, also enhancing developmental competence. The mechanisms that underlie their actions in antral follicles, as well as the targets ultimately controlled by these factors, are beginning to emerge. GDNF, BDNF and NGF, alone or in combination, could be added to the media currently utilized for in vitro oocyte maturation, thereby potentially increasing the production and/or quality of early embryos.Reproduction (2013) 145 R43-R54

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“…12 Furthermore, a recent study revealed that Pak1 and Pak2 could mediate tumor cell invasion through distinct signaling mechanisms in breast carcinoma cells. 13 In this study, we investigated the expression and prognostic significance of Pak1, p-Pak1 Thr 212 , Pak2 and p-Pak2 Ser 20 in ovarian cancer. The effects of Pak1 and Pak2 on cell migration, invasion, proliferation and apoptosis were investigated as an attempt to determine whether Pak1 and Pak2 are involved in the progression of ovarian tumors and thus be useful as molecular prognostic markers and therapeutic targets for ovarian cancer.…”

mentioning

confidence: 99%

Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion

Siu

Wong

Chan

et al. 2010

Intl Journal of Cancer

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Ovarian cancer is a gynecological malignancy with high mortality. Therefore, the identification of novel prognostic and therapeutic targets is important. p21‐activated kinases (Paks) are involved in cytoskeleton reorganization. This study investigated the clinical significance of total and phosphorylated (p) Pak1 and Pak2 as well as their functional roles in ovarian cancer. Expressions of Pak1, p‐Pak1 Thr212, Pak2 and p‐Pak2 Ser20 in ovarian normal and cancerous cell lines as well as in clinical samples of ovarian tumors were evaluated. The effects of Pak1 and Pak2 on ovarian cancer cell functions were determined. Pak1, p‐Pak1 and p‐Pak2 were overexpressed in ovarian cancer cell lines, and clinical samples of ovarian cancers were compared with benign ovarian lesions/inclusion cysts. Similar Pak2 expression levels were observed among normal and cancerous cell lines and clinical samples. After multiple testing correction, high Pak1 and nuclear p‐Pak1 expression in ovarian cancers was significantly associated with histological type and tumor grade, respectively. Pak1 and p‐Pak1 expression was associated with poor overall and disease‐free survival. Pak1 was an independent prognostic factor. Knockdown of Pak1 and Pak2 in ovarian cancer cell lines reduced cell migration and invasion but did not affect cell proliferation and apoptosis. Knockdown of Pak1 also reduced p38 activation and downregulated vascular endothelial growth factor. Conversely, ectopic Pak1 overexpression enhanced ovarian cancer cell migration and invasion in a kinase‐dependent manner, along with increased p38 activation. Our findings suggest that Pak1, p‐Pak1 and p‐Pak2 play important roles in ovarian carcinogenesis. Pak1 and p‐Pak1 may be potential prognostic markers and therapeutic molecular targets in ovarian cancer.

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Tyrosine kinase B receptor and BDNF expression in ovarian cancers – Effect on cell migration, angiogenesis and clinical outcome

Cited by 117 publications

References 38 publications

Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma

Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma

The roles of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor and nerve growth factor during the final stage of folliculogenesis: a focus on oocyte maturation

Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion

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