Tyrosine kinase inhibitors suppress prostaglandin F2α-induced phosphoinositide hydrolysis, Ca2+ elevation and contraction in iris sphincter smooth muscle

Yousufzai, Sardar Y.K.; Abdel‐Latif, Ata A.

doi:10.1016/s0014-2999(98)00697-9

Cited by 16 publications

(11 citation statements)

References 38 publications

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“…Cancer (Breast) (Morito et al, 2001) 1awn Guanylyl cyclase Cancer (Theodorescu et al, 1998) 1azm Carbonic anhydrase I Kidney failure (Tomobe et al, 1998), Glaucoma (Yousufzai and Abdel-Latif, 1998), Cancer (Theodorescu et al, 1998) 1b3o Inosine dehydrogen Malaria (Dluzewski and Garcia, 1996) 1bbz ABL tyrosine kinase Tyrosine kinase inhibitor (Nishimura et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation

Chen

Zhou

Liu

et al. 2006

British J Pharmacology

195

137

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Background and purpose: Traditional Chinese Medicine (TCM) is widely practised and is viewed as an attractive alternative to conventional medicine. Quantitative information about TCM prescriptions, constituent herbs and herbal ingredients is necessary for studying and exploring TCM. Experimental approach: We manually collected information on TCM in books and other printed sources in Medline. The Traditional Chinese Medicine Information Database TCM-ID, at http://tcm.cz3.nus.edu.sg/group/tcm-id/tcmid.asp, was introduced for providing comprehensive information about all aspects of TCM including prescriptions, constituent herbs, herbal ingredients, molecular structure and functional properties of active ingredients, therapeutic and side effects, clinical indication and application and related matters. Results: TCM-ID currently contains information for 1,588 prescriptions, 1,313 herbs, 5,669 herbal ingredients, and the 3D structure of 3,725 herbal ingredients. The value of the data in TCM-ID was illustrated by using some of the data for an in-silico study of molecular mechanism of the therapeutic effects of herbal ingredients and for developing a computer program to validate TCM multi-herb preparations. Conclusions and Implications: The development of systems biology has led to a new design principle for therapeutic intervention strategy, the concept of 'magic shrapnel' (rather than the 'magic bullet'), involving many drugs against multiple targets, administered in a single treatment. TCM offers an extensive source of examples of this concept in which several active ingredients in one prescription are aimed at numerous targets and work together to provide therapeutic benefit. The database and its mining applications described here represent early efforts toward exploring TCM for new theories in drug discovery.

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Section: Discussionmentioning

confidence: 99%

Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation

Chen

Zhou

Liu

et al. 2006

British J Pharmacology

195

137

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“…24 PIs is one of the known classes of phospholipids that undergoes significant changes during the administration of PG analogs for IOP lowering. 25,26 Endogenous lipids in the anterior chamber may be involved in regulation of aqueous outflow, outflow facility, and IOP. The previous techniques, such as various forms of chromatography and nuclear magnetic resonance, necessitated knowledge of several different chemistries due to different chemical behavior of different lipid species even within a class, and the requirement of large amounts (microgram quantities) of lipids for identification and characterization.…”

Section: Discussionmentioning

confidence: 99%

Comparative Phospholipid Profiles of Control and Glaucomatous Human Trabecular Meshwork

Aribindi¹,

Guerra²,

Lee³

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…Activation of PG receptors leads to an array of effects in a range of cell and tissue types, including skeletal muscle. PGs activate increases in intracellular calcium within a variety of muscle cell types [Asboth et al, 1996;Chen et al, 1997;Yew et al, 1998;Yousufzai and Abdel-Latif, 1998]. Specifically, PGF 2· activates increases in intracellular calcium through the PGF 2· receptor (FP) [Breyer et al, 2001].…”

Section: Pgf 2· In Myoblast Fusion and Muscle Growthmentioning

confidence: 99%

Forming a Multinucleated Cell: Molecules That Regulate Myoblast Fusion

Horsley

Pavlath²

2004

Cells Tissues Organs

213

198

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In mammals, cell fusion occurs among a limited number of cell types: sperm and oocytes during fertilization, trophoblasts during placenta formation, macrophages during giant cell and osteoclast formation and myoblasts in the formation of myofibers and myotubes. The molecular mechanisms involved in these membrane fusion events largely are unknown. This review will focus on the known molecules that regulate myoblast fusion with an emphasis on a novel signaling pathway involving the calcium-regulated transcription factor NFATC2 in the regulation of myoblast fusion.

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Tyrosine kinase inhibitors suppress prostaglandin F2α-induced phosphoinositide hydrolysis, Ca2+ elevation and contraction in iris sphincter smooth muscle

Cited by 16 publications

References 38 publications

Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation

Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation

Comparative Phospholipid Profiles of Control and Glaucomatous Human Trabecular Meshwork

Forming a Multinucleated Cell: Molecules That Regulate Myoblast Fusion

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