2019
DOI: 10.1021/acs.molpharmaceut.9b00426
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Tyrosine Phosphorylation Regulates Plasma Membrane Expression and Stability of the Human Bile Acid Transporter ASBT (SLC10A2)

Abstract: The human apical sodium-dependent bile acid transporter (hASBT; SLC10A2) is responsible for the reclamation of bile acids from the intestinal lumen, providing a primary mechanism for bile acid and cholesterol homeostasis. However, the regulation of hASBT at the post-translational level is not well understood. In the present study, we investigated the role of Src family kinases (SFKs) and protein tyrosine phosphatases (PTPs) in the regulation of surface expression and function of hASBT. Inhibition of Src family… Show more

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Cited by 12 publications
(2 citation statements)
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“…Through the action of gut microbiota, primary BAs are converted into secondary BAs, such as deoxycholic acid (DCA), lithocholic acid (LCA), and UDCA. Subsequently, a small portion of unconjugated BAs is reabsorbed through passive diffusion in the anterior small intestine, whereas 95% of the BAs are efficiently reabsorbed in the terminal ileum via apical sodium-dependent BA transporter (ASBT) [ 46 ] and then transported to the basolateral membrane through ileal BA-binding protein. Thereafter, the organic solute transporter-α/β (OSTα/β) facilitates the entry of BAs into the portal vein blood circulation [ 47 ].…”
Section: Ba Homeostasismentioning
confidence: 99%
“…Through the action of gut microbiota, primary BAs are converted into secondary BAs, such as deoxycholic acid (DCA), lithocholic acid (LCA), and UDCA. Subsequently, a small portion of unconjugated BAs is reabsorbed through passive diffusion in the anterior small intestine, whereas 95% of the BAs are efficiently reabsorbed in the terminal ileum via apical sodium-dependent BA transporter (ASBT) [ 46 ] and then transported to the basolateral membrane through ileal BA-binding protein. Thereafter, the organic solute transporter-α/β (OSTα/β) facilitates the entry of BAs into the portal vein blood circulation [ 47 ].…”
Section: Ba Homeostasismentioning
confidence: 99%
“…The regulation of phosphorylation level of tyrosine residues is centrally important to cellular function in eukaryotic cells, which is controlled by the concerted action of two classes of enzymes: protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) 1‐4 . Human epidermal growth factor receptor‐2 (HER2) protein, a member of the EGFR family, forms homologous or heterodimer with other members of the EGFR family upon the action of growth factors, which could activate downstream cellular signaling pathways and have an influence on cell function 5‐10 .…”
Section: Introductionmentioning
confidence: 99%