Tyrosine-rich crystalloids in a polymorphous low-grade adenocarcinoma

Raubenheimer, Erich J.; Heerden, W.F.P. Van; Thein, Thomas

doi:10.1016/0030-4220(90)90215-e

Cited by 22 publications

(11 citation statements)

References 9 publications

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“…Although reported in different salivary gland neoplasms they seem to be more common in pleomorphic adenomas and PCA. 8,25,26 The cytopathologists must be familiar with their morphology since their presence will favor one of these diagnoses. Finally, the similarities between PAC and papillary thyroid carcinoma 27 can raise diagnostic problems in the case of cervical metastases.…”

Section: Discussionmentioning

confidence: 99%

Fine needle aspiration cytology of polymorphous adenocarcinoma of the salivary glands: A report of 11 patients and review of the literature

Jiménez‐Heffernan

Rodríguez-García

González‐Peramato

et al. 2020

Diagnostic Cytopathology

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Background: Polymorphous adenocarcinoma (PAC) is a rare malignant tumor of the minor salivary glands. It has an infiltrative growth, variable architectural patterns, neurotropism and cellular monomorphism. Approximately 75% of the cases show a specific mutation in the protein kinase D1 (PRKD1) gene. Reflecting the rarity of the tumor and intraoral location, the cytologic experience is limited with few reported series. In this study we analyze our cytologic experience to determine if a preoperative diagnosis is possible. Methods: A retrospective study of 11 patients with PAC in which a cytologic study was available. A review of the literature was also performed. Results: Our study shows that PAC has relatively constant cytological features. The analysis of the cytological literature although it shows some heterogeneity, also reveals repetitive cytological findings. Smears are cellular with irregular groups some showing pseudopapillary branching morphology. Monolayered clusters and small acinar structures are also present. Most cases have small metachromatic globules embedded within the groups determining a cylindromatous pattern. Tumoral cells are small and uniform with scarce to moderate cytoplasm. Nuclei are round and oval with occasional grooves and small nucleoli. Conclusion: PAC has characteristic cytological features that together with its location in minor salivary gland must make us consider it preoperatively. It may resemble basal cell adenoma and epithelial-rich pleomorphic adenoma so we should be cautious in the final diagnosis. Whenever possible, the characteristic cytomorphology of PCA should make us evaluate the mutational status of PRKD1 gene since it may permit a more accurate diagnosis.

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Section: Discussionmentioning

confidence: 99%

Fine needle aspiration cytology of polymorphous adenocarcinoma of the salivary glands: A report of 11 patients and review of the literature

Jiménez‐Heffernan

Rodríguez-García

González‐Peramato

et al. 2020

Diagnostic Cytopathology

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“…In 3-5% of cases of PLGA, crystals resembling the tyrosine-rich crystals of some pleomorphic adenomas can be found. 102,103 None of these features were ever described in CAMSG.…”

Section: Differential Diagnosismentioning

confidence: 99%

Newly described salivary gland tumors

2017

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This review concentrates on three salivary gland tumors that have been accepted in the recent literature as new neoplastic entities: mammary analog secretory carcinoma (MASC), sclerosing polycystic adenoma (SPA) and cribriform adenocarcinoma of tongue and other minor salivary glands (CAMSGs). MASC is a distinctive low-grade malignant salivary cancer that harbors a characteristic chromosomal translocation, t(12;15) (p13;q25) resulting in an ETV6-NTRK3 fusion. SPA is a rare lesion often mistaken histologically for low-grade salivary carcinoma. Previously thought to be a reactive fibroinflammatory process, but recent evidence of clonality, recurrences in up 30%, and dysplastic foci suggest it may be truly neoplastic. CAMSG is a distinct tumor entity that differs from polymorphous low-grade adenocarcinoma (PLGA) by location (ie, most often arising on the tongue), by prominent nuclear clearing, alterations of the PRKD gene family and clinical behavior with frequent metastases at the time of presentation of the primary tumor. Early metastatic disease seen in most cases of CAMSG associated with indolent behavior makes it a unique neoplasm among all low-grade salivary gland tumors. Salivary glands may give rise to a wide spectrum of different tumors. They are often diagnostically challenging as morphological features often overlap between different entities. Although conventional morphology in combination with immunohistochemical findings still provide the most important clues for diagnosis, recent advances in molecular pathology offer new diagnostic tools in investigating the differential diagnosis, as well as providing potentially valuable prognostic indicators. In the last two decades, several new salivary gland tumor entities have been described, namely MASC, SPA and CAMSGs.

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“…At the cellular level, PLGA quite often contains clear cells and less frequently, mucous cells. In 3-5 % of cases of PLGA, crystals resembling the tyrosine rich crystals of some pleomorphic adenomas can be found [13,14]. None of these features have ever been described in CATMSG.…”

Section: Differential Diagnosismentioning

confidence: 99%

Cribriform Adenocarcinoma of the Tongue and Minor Salivary Glands: A Review

Michal

Kacerovská

Kazakov

2013

Head and Neck Pathol

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Cribriform adenocarcinoma of the tongue and minor salivary glands (CATMSG) is a tumor occurring mostly, but not exclusively, in the base of the tongue. Other locations are minor salivary glands of the oral cavity. Histopathologically, CATMSG resembles papillary carcinoma of the thyroid gland. It usually reveals a solid growth devoid of colloid, and eosinophilic material present in follicular areas is rather pale in contrast to metastatic foci seen in papillary thyroid carcinoma that shows typical deeply eosinophilic colloid with ''moth-eaten peripheries'' and cystic configuration. In addition, giant multinucleated cells are not observed in CATMSG and psammoma bodies are found only exceptionally. Unlike papillary thyroid carcinoma, CATMSG is composed of hybrid secretorymyoepithelial cells. Most importantly, CATMSG is consistently negative with both thyroglobulin and TTF-1. CATMSG is a distinct tumor entity that also differs from polymorphous low-grade adenocarcinoma by location, cytology, histological architecture, and behavior, with frequent metastases at the time of presentation. Paradoxically, early metastatic disease seen in most cases of CATMSG is associated with an indolent behavior. It makes CATMSG a unique neoplasm among all low-grade salivary gland tumors.

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Tyrosine-rich crystalloids in a polymorphous low-grade adenocarcinoma

Cited by 22 publications

References 9 publications

Fine needle aspiration cytology of polymorphous adenocarcinoma of the salivary glands: A report of 11 patients and review of the literature

Fine needle aspiration cytology of polymorphous adenocarcinoma of the salivary glands: A report of 11 patients and review of the literature

Newly described salivary gland tumors

Cribriform Adenocarcinoma of the Tongue and Minor Salivary Glands: A Review

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