2024
DOI: 10.1101/2024.03.06.583706
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U-FISH: a universal deep learning approach for accurate FISH spot detection across diverse datasets

Weize Xu,
Huaiyuan Cai,
Qian Zhang
et al.

Abstract: In the rapidly advancing landscape of fluorescence in situ hybridization (FISH) technologies, there is a critical need for sophisticated yet adaptable methods for spot detection. This study introduces U-FISH, a deep learning approach that significantly improves accuracy and generalization capabilities. Our method utilizes a U-Net model to transform noisy and ambiguous FISH images into a standardized representation with consistent signal characteristics, facilitating efficient spot detection. For the training a… Show more

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