U. Güller et al.: Neurogene Appendicopathie: Ein häufiges, fast unbekanntes Krankheitsbild. Auswertung von 816 Appendices und Literaturübersicht Der Chirurg (2001) 72: 684

Franke, C.

doi:10.1007/s001040170019

Chirurg

2001

DOI: 10.1007/s001040170019

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U. Güller et al.: Neurogene Appendicopathie: Ein häufiges, fast unbekanntes Krankheitsbild. Auswertung von 816 Appendices und Literaturübersicht Der Chirurg (2001) 72: 684

C. Franke

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Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis

2022

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In 1921; Masson and Maresch first coined the term “neurogenic appendicitis (NA)” to describe “neuroma-like” lesions in the appendix. To date, our knowledge about NA is limited; therefore, we conducted a comprehensive analysis of the literature (1921 to 2020) to examine the clinicopathological features of NA. We also addressed the pathophysiology of acute abdominal pain and fibrosis in this entity. We performed a meta-analysis study by searching the PubMed database, using several keywords, such as: “appendix,” “neurogenic,” “obliterative,” “neuroma,” “fibrous obliteration,” “appendicopathy,” and “appendicitis.” Our study revealed that patients with NA usually present clinically with features of acute appendicitis, bud2t they have grossly unremarkable appendices. Histologically, the central appendiceal neuroma was the most common histological variant of NA, followed by the submucosal and intramucosal variants. To conclude, NA represents a form of neuroinflammation. The possibility of NA should be considered in patients with clinical features of acute appendicitis who intraoperatively show a grossly unremarkable appendix. Neuroinflammation and neuropeptides play roles in the development of pain and fibrosis in NA.

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Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis

2022

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U. Güller et al.: Neurogene Appendicopathie: Ein häufiges, fast unbekanntes Krankheitsbild. Auswertung von 816 Appendices und Literaturübersicht Der Chirurg (2001) 72: 684

Cited by 1 publication

References 5 publications

Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis

Neurogenic Appendicitis: A Reappraisal of the Clinicopathological Features and Pathogenesis

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