Sapphirine granulites from a new locality in the Palni Hill Ranges, southern India, occur in a small enclave of migmatitic, highly magnesian metapelites (mg=85-72) within massive enderbitic orthogneiss. They show a variety of multiphase reaction textures that partially overprint a coarse-grained high-pressure assemblage of Bt+Opx+Ky+Grt+Pl+Qtz. The sequence of reactions as deduced from the corona and symplectite assemblages, together with petrogenetic grid considerations, records a clockwise P-T evolution with four distinct stages. (1) Equilibration of the initial high-P assemblage in deep overthickened crust (12 kbar/800-900°C) was followed by a stage of near-isobaric heating, presumably as a consequence of input of extra heat provided by the voluminous enderbitic intrusives. During heating, kyanite was converted to sillimanite, and biotite was involved in a series of vapour-phase-absent melting reactions, which resulted in the ultra-high-temperature assemblage Opx+Crd+Kfs+Spr±Sil, Grt, Qtz, Bt, coexisting with melt (equilibration at c. 950-1000°C/11-10 kbar). (2) Subsequently, as a result of decompression of the order of 4 kbar at ultra-high temperature, a sequence of symplectite assemblages (Opx+Sil+Spr/ Spr+Crd Opx+Spr+Crd Opx+Crd Opx+Crd+Spl/Crd+Spl) developed at the expense of garnet, orthopyroxene and sillimanite. This stage of near-isothermal decompression implies rapid ascent of the granulites into mid-crustal levels, possibly due to extensional collapse and erosion of the overthickened crust. (3) Development of late biotite through back-reaction of melt with residual garnet indicates a stage of near-isobaric cooling to c. 875°C at 7-8 kbar, i.e. relaxation of the rapidly ascended crust to the stable geotherm. (4) A second period of near-isothermal exhumation up to c. 6-5 kbar/850°C is indicated by the partial breakdown of late biotite through volatile phase-absent melting reactions. Available isotope data suggest that the early part of the evolutionary history (stages 1-3) is presumably coeval with the early Proterozoic metamorphism in the extended granulite terrane of the Nilgiri, Biligirirangan and Shevaroy Hills to the north, while the exhumation of the granulites from mid-crustal levels (stage 4) occurred only during the Pan-African thermotectonic event, which led to the accretion of the Kerala Khondalite Belt to the south.