U-Shaped and Surface Functionalized Polymer Optical Fiber Probe for Glucose Detection

Azkune, Mikel; Ruiz‐Rubio, Leire; Aldabaldetreku, Gotzon; Arrospide, Eneko; Zubía, Joseba; Vilas, José Luis

doi:10.3390/s18010034

Cited by 31 publications

(19 citation statements)

References 26 publications

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“…Azkune in 2018 recorded and compared different glucose absorption spectra in plastic optical fibers doped with methyl methacrylate. These tests are performed by immersing the sensor for 10 min in different glucose concentrations ranging from 0 to 25 mM [87]. In 2019, normalized gamma spectra in a visible range of 450 to 500 nm for different glucose concentrations were located, showing a change in intensity and a shift to the right [88].…”

Section: Plastic Fiber Optic Sensorsmentioning

confidence: 99%

Fiber Optic Sensors: A Review for Glucose Measurement

et al. 2021

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Diabetes mellitus is a chronic metabolic disorder, being globally one of the most deadly diseases. This disease requires continually monitoring of the body’s glucose levels. There are different types of sensors for measuring glucose, most of them invasive to the patient. Fiber optic sensors have been proven to have advantages compared to conventional sensors and they have great potential for various applications, especially in the biomedical area. Compared to other sensors, they are smaller, easy to handle, mostly non-invasive, thus leading to a lower risk of infection, high precision, well correlated and inexpensive. The objective of this review article is to compare different types of fiber optic sensors made with different experimental techniques applied to biomedicine, especially for glucose sensing. Observations are made on the way of elaboration, as well as the advantages and disadvantages that each one could have in real applications.

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Section: Plastic Fiber Optic Sensorsmentioning

confidence: 99%

Fiber Optic Sensors: A Review for Glucose Measurement

et al. 2021

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“…There is a wide range of application fields where the detection and quantification of different substances in low concentration are indispensable requirements, as well as clinical diagnosis, food safety, drug discovery or evaluation of hazardous contaminants, among others. Development of solutions based on polymer optical fibers (POF) in combination with highly functional matrixes, such as hydrogels, fit well with the aforementioned needs [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogel-Core Microstructured Polymer Optical Fibers for Selective Fiber Enhanced Raman Spectroscopy

Azkune

Ayesta

Ruiz‐Rubio

et al. 2021

Sensors

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A new approach of Fiber Enhanced Raman Spectroscopy (FERS) is described within this article based on the use of Hydrogel-Core microstructured Polymer Optical Fibers (HyC-mPOF). The incorporation of the hydrogel only on the core of the Hollow-Core microstructured Polymer Optical Fiber (HC-mPOF) enables to perform FERS measurements in a functionalized matrix, enabling high selectivity Raman measurements. The hydrogel formation was continuously monitored and quantified using a Principal Component Analysis verifying the coherence between the components and the Raman spectrum of the hydrogel. The performed measurements with high and low affinity target molecules prove the feasibility of the presented HyC-mPOF platform.

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“…This can impact homogeneity of the coating and lower the efficiency bond between PMMA and the recipient tissue, making these approach impractical for the clinical translation. 11 Recent studies to functionalize PMMA surfaces includes: large-area nanopatterning with cell adhesive peptides, 35 atmospheric pressure plasma plasma-assisted copolymerization of methyl methacrylate (MMA) with a vinyl derivative of L-DOPA, followed by deposit coating with reactive catechol/quinone groups suitable for protein covalent immobilization, 36 PMMA-MA nanoparticle surface modification with azide/carboxylate bifunctional group to enable assembly of small nanoparticle and their further coupling with oligonucleotides, 37 vaporphase nanopatterning of PMMA with aminosilanes via electron beam lithography, 38 surface functionalized of PMMA-based optical fiber probe with phenilboronic groups for glucose detection, 39 and hydrothermally treating the electrospun PMMA nanofibers with titanium nbutoxide precursor to form TiO 2 nanoparticles supported on PMMA nanofibers for photocatalytic degradation of methyl orange. 40 In this study, we covalently functionalized the PMMA surface with an L-3,4-dihydroxyphenylalanine amino acid (L-DOPA) and have studied cytotoxicity, biocompatibility, and the structural properties of coated PMMA, along with the interfacial adhesion strength of coated PMMA with human corneal tissues ( Figure 1b).…”

Section: Introductionmentioning

confidence: 99%

Covalent Functionalization of PMMA Surface with L‐3,4‐Dihydroxyphenylalanine (L‐DOPA) to Enhance its Biocompatibility and Adhesion to Corneal Tissue

Sharifi

Mahmoudzadeh

Islam

et al. 2019

Adv Materials Inter

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The Boston keratoprosthesis (B-KPro) is globally the most commonly implanted artificial cornea for patients with severe corneal diseases, particularly those with multiple allograft failures. Despite providing a good visual recovery, the poor adhesion between the poly (methyl methacrylate) [PMMA]-made stem and the donor tissue poses a challenge, impacting the clinical outcome of the B-KPro. Using single-molecule covalent bonding, we herein functionalized PMMA surface with L-3,4-dihydroxyphenylalanine (L-DOPA) and studied its chemical, optical, mechanical, and biological properties. We have shown that the functionalization process alters the surface properties of the PMMA device and significantly improves its biocompatibility, without affecting the optical and mechanical properties of PMMA. Live/Dead assays showed that human corneal fibroblasts (HCF) seeded on L-DOPA surface have greater confluency (62.2  2.4%) compared to those of PMMA (19.1  1.8%) after 7 days of cell culture. In addition, HCF cultured on L-DOPA exhibited significantly higher metabolic rate (nearly twice) compared to those of PMMA, as indicated by AlamarBlue assay. Human corneal epithelial cells (HCEp) cultured on non-treated and treated PMMA also demonstrated a similar response. Moreover, immunocytochemistry revealed that HCF cultured on L-DOPA have a higher expression of ALDH3A1, Ki67, Integrin 1, and FAK with no expression of -SMA, compared to those of PMMA, which instead demonstrated greater expression of -SMA. These suggest that L-DOPA surface fosters cellular adhesion, proliferation, and migration, without adverse impact on the phenotype of the cells. This study offers an inexpensive and efficient tactic to covalently This article is protected by copyright. All rights reserved. modify the surface of materials such as PMMA with L-DOPA in order to achieve the optimal biocompatibility and biointegration of medical devices.

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U-Shaped and Surface Functionalized Polymer Optical Fiber Probe for Glucose Detection

Cited by 31 publications

References 26 publications

Fiber Optic Sensors: A Review for Glucose Measurement

Fiber Optic Sensors: A Review for Glucose Measurement

Hydrogel-Core Microstructured Polymer Optical Fibers for Selective Fiber Enhanced Raman Spectroscopy

Covalent Functionalization of PMMA Surface with L‐3,4‐Dihydroxyphenylalanine (L‐DOPA) to Enhance its Biocompatibility and Adhesion to Corneal Tissue

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