Über Aktivierung von Cholinesterasen durch Alkylphosphatein vivo

The Part Played by Inhibition of Cholinesterases of the CNS in Producing Paralysis in Chickens

“…This was particularly marked following DFP. Koelle and Gilman (1946) and Locker and Siedek (1952) have reported a significant increase in blood and tissue cholinesterase over pre-exposure levels after dosing with anticholinesterases. Koelle and Gilman also noted this in rats, but did not comment on it.…”

Auditory detection behavior in parathion treated squirrel monkeys

“…After a single 0.1 mg/kg feeding of parathion to guinea pigs, Locker and Siedek (1952) reported a 10 percent decrease in brain cholinesterase and a 50 percent decrease in liver cholinesterase within 2 days following exposure. Plasma cholinesterase increased within 6 days to 150 percent of the pre-exposed level.…”

“…Central nervous system cholinesterases are inhibited by parathion (Grob et al, 1949;Grob et al, 1950;Locker and Siedek, 1952;Reiff et al. 1971).…”

Delayed matching to sample performance and parathion toxicity in the squirrel monkey (Saimiri sciureus)

“…Ae data reviewed support a number of general conclusions related to cholinesterase activity following exposure to organophosphorous compounds in both animals and humans. First, a significant inhibition of cholin esterase activity can occur as the result of relatively low (less than 2 ppm) exposures to organophosphorous compounds in both animals (Bajgar, 1971;Frawley et al, 1952;Frawley & Fuyat, 1957;Locker & Siedek, 1952;Reiff et alf 1971;Reiter et al, 1973;Reiter et al, 1975;Vijayan & Brovmson, 1975) and humans (Edson, 1957;Hartwell et al, 1964;Rider et al, 1969). Second, chronic exposures do produce a cumulative inhibition of cholinesterase activity in both animals (Frawley & Fuyat, 1957;Reiter et al, 1973) and humans (Edson, 1957;Murphy, 1975;Rider et al, 1969), at ejcposure levels which acutely result in no significant enzyme inhibition.…”