“…Jores (1904), Hueck (1920), Burger and Schlomka (1928), Winternitz, et (1938), Aschoff (1939), and Simms (1942) were few of the earlier workers who proposed that the intimai and arteriosclerotic changes were the result of physiologi cal aging process and may or may not be modified by addi tional vasoactive factors. The above view has also been put forth recently by a number of workers; Buerger and Hevelke (1956), Movat, et al (1958), Lindsay and Chaikoff (I963).…”