Über Darstellung von Dehydracetsäure aus Acetessigester und über den Mechanismus dieser Reaktion

Potassium fluoride-barium oxide catalysis in an easy and efficient synthesis of methysticin from piperonal under microwave irradiation

“…Synthesis of 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one (I) was based on the method presented earlier [28][29][30]. The reaction of two equivalents of β-ketoester in the presence of Na 2 CO 3 (Scheme 2) led to DHA (I) (yield 80%).…”

Natural Product Synthesis: Changes over Time

“…This concept means that these skeleton-building reactions are reliable, chiefly being confined to malonic ester synthesis, Dieckmann cyclization, and Reformatsky reactions. In this context, the use of Arndt-Eistert homologation, [8] which was considered very recent at the time, appears to be quite revolutionary. It is quite instructive to realize how few reactions natural product synthesis had at its disposal.…”

Naturstoffsynthese im Wandel der Zeit

“…Das heißt, die Aufbaureaktionen beschränken sich auf Malonestersynthese, Dieckmann-Cyclisierung und Reformatsky-Reaktion. Die Anwendung deraus damaliger Sicht -erst kurz zuvor entdeckten Arndt-Eistert-Homologisierung [8] mutet in dieser Konstellation schon revolutionär an. Es ist instruktiv, sich klar zu machen, mit wie wenigen Reaktionen die Chemiker damals Naturstoffsynthese betrieben.…”