Über das Fäulnisgift Sepsin

Faust, Edwin Stanton

doi:10.1007/bf01840606

Cited by 27 publications

(3 citation statements)

References 5 publications

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“…Albeck (9) believed that it belonged in the group of putrefactive poisons. Murphy and Brooks (7) believe that it may be similar to the substance sepsin isolated by Faust (10). It has been suggested that it might resemble the ~-iminazolyl ethylamine of Dale (11).…”

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confidence: 86%

Intestinal Obstruction

Whipple

Rodenbaugh

Kilgore

1916

Journal of Experimental Medicine

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In earlier publications Whipple, Stone, and Bernheim (1, 2, 3, 4) have established facts which have an important bearing on this question of proteose intoxication. Some of these points will be reviewed, but for the detailed experiments the original papers should be consulted. In this work closed loops of intestine have been used because it has been established by previous experiments that an acute intoxication develops, and the toxic substance may be obtained in concentrated form in the material which accumulates in the closed loops. The intoxication noted in simple intestinal obstruction is similar, but usually less intense than that observed in dogs with closed or drained duodenal loops. Much evidence has been furnished to demonstrate that the essential toxic substance is very similar or even identical in obstruction and in closed intestinal loops.All recent work speaks strongly for the theory of a definite intoxication in intestinal obstruction and closed loops of intestine. The doubts expressed by Hartwell and Hoguet (5) have been answered by Draper (6). Hartwell and Hoguet claimed that loss of fluid and consequent dehydration of the tissues were primary and the intoxication a secondary result of this dehydration. Whipple, Stone, and Bernheim have claimed that the intoxication was primary and the dehydration of the tissues secondary to the intoxication. Draper has been able to show that a dog can be dehydrated in four days by pilocarpin to the same degree encountered in duodenal obstruction. One of us has been able to bring about a similar dehydration and blood concentration by means of pilocarpin and vigorous salt purgation 123 on

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confidence: 86%

Intestinal Obstruction

Whipple

Rodenbaugh

Kilgore

1916

Journal of Experimental Medicine

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“…Heubner mentions a number of other substances which act as capillary poisons. These include a number of double salts of heavy metals, belonging to the gold and iron groups, arsenic and the organic bases emetine and sepsine (Faust, 1904). Several of these show, of course, other toxic properties beyond that exercised upon the capillary wall, which latter becomes dominant only when they are introduced in suitable concentration directlv into the blood.…”

Section: A Comparison Between Two Of the Experiments Ofmentioning

confidence: 99%

The Anatomy and Physiology of Capillaries.

1929

JAMA

251

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also steadily maintained at about the size of recent editions has once more been skilfully managed. Undulant fever has its first mention ; the sections on dengue fever, pulmonary abscess and ulcerative colitis have been rewritten, and plates VI and VII, illustrating the roentgenoscopic features of pulmonary disease, are new ; also many other illustrations. On the whole, only alterations in keeping with studious attention to the needs of yearly revisions have been made.

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Section: The Reactions Of Capillaries To Lightmentioning

confidence: 99%

The Anatomy and Physiology of Capillaries.

1923

JAMA

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In 1910, Sir Arthur Pearson retired from business because of approaching blindness. When the war came he devoted his fortune to building an institution for the care and education of the war blind. This book records the work done at St. Dunstan's by Lawson, who had under his care 825 persons totally incapacitated by blindness. The book is divided into three parts: (1) traumatic blindness; (2) nontraumatic blindness; (3) pensions and reeducation of the blind. There were 407 traumatic cases: 72 caused by bullets passing through the orbits, 17 of fracture of the occipital portion of the skull, 12 of fracture of the skull other than occipital, 16 of concussion blindness without direct wound or penetration of the globe, and 289 miscellaneous cases of blindness from premature explosions of bombs, explosive bullets, aeroplane accidents and burns. There was a notable absence of sympathetic inflammation. There were 417 cases of nontraumatic blindness, a review of which led to some conclusions concerning enlistment. In the examination of men for military ser¬ vice, those who have had disease of the uveal tract of both eyes should be rejected. When only one eye is involved, as the result of traumatic uveal inflammation, the man should not be accepted. A careful ophthalmologic examina¬ tion should be made to rule out congenital disease, such as retinitis pigmentosa, or some chronic disease, such as chorioretinitis, thus saving the state much money in pensions. Interstitial keratitis and other varieties of inflammatory dis¬ ease were found in 138 cases, of which 47 were interstitial. There were 109 cases of primary optic nerve disease, of which 62 were positively the result of syphilis and 18 more were clinically so classified. Secondary optic nerve degeneration gave 44 cases due to syphilis, cerebral tumor and meningitis.Blindness due to detachment of the retina was found in 29 cases; family atrophy, in 17; glaucoma, in 11; cataract, in 7; traumatic neurasthenia, in 4; bilateral embolism of the central retinal artery, in 2, and pituitary disease in 3. There was one each of recurrent retinal hemorrhage, exophthalmic goiter, retinitis proliferans and meningitis. Syphilis as a cause of nontraumatic blindness in the war is well shown by this review. The third part deals with pensions and the reeduca¬ tion of the blind. The author well contends that men blinded by disease brought on by unfavorable conditions in the war should be pensioned. The question of syphilis and war blind¬ ness was finally settled so that men were given pensions who had loss of vision due to a syphilitic lesion, acquired or congenital, with or without a positive Wassermann reaction. That section of the book dealing with reeducation is brief, and gives an accurate picture of the difficulties and problems of this phase of the work among the war blind which ought to be known by every ophthalmologist. Trait\l=e'\pratique de cystoscopie et de cath\l=e'\t\l=e'\rismeur\l=e'\t\l=e'\ral. Par G. Marion, Professeur agr\l=e'\ge \l=a`\la Facult\l=e'\,Chirurgien de l'H\l=...

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Über das Fäulnisgift Sepsin

Cited by 27 publications

References 5 publications

Intestinal Obstruction

Intestinal Obstruction

The Anatomy and Physiology of Capillaries.

The Anatomy and Physiology of Capillaries.

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