Über das krystallisierte Vitamin D<sub>1</sub>

Windaus, A.; Lüttringhaus, Arthur; Deppe, M.

doi:10.1002/jlac.19314890114

Cited by 31 publications

(9 citation statements)

References 19 publications

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“…Irradiation of food items (e.g., milk butterfat, dietary oil) could also impart antirachitic potency. Due to this, the history of vitamin D research was closely related to UV-irradiated compounds (Windaus et al, 1931;Karlson, 1981). The story of D-vitamin research was perhaps best reviewed by Wolf (2004).…”

Section: A Brief History Of Vitamin D Researchmentioning

confidence: 99%

“…Hinton (quoted in Sláma et al, 1974), "the terms of science should correspond with the facts in nature". As ecdysteroids are neither arthropod moulting hormones (Sláma, 1983) nor stimulate ecdysis and have strong anabolic, vitamin D-like effects, it is more appropriate to use the generic term vitamin D 1 , although it was originally proposed for a structurally unidentifi ed UVirradiation product of ergosterol by Windaus et al (1931).…”

Section: History Of Ecdysteroidsmentioning

confidence: 99%

“…The credibility of the theory of UV-based activation of secosterol vitamins D 2 and D 3 in the skin (Windaus et al, 1931;Windaus & Bock, 1937), however, needs to be reexamined. Who knows where vegetarians get their essential vitamin D from, if it is an animal sterol?…”

Section: Th E Neglected Role Of Vitamin D 1 In Human Health Carementioning

confidence: 99%

“…According to Karlson (1981), the status of vitamin D 1 was not clear. It was a crystalline substance isolated by Windaus et al (1931) from ultraviolet irradiated ergosterol. Previous investigators predicted that vitamin D might be somewhat related to 7-dehydrocholesterol (Hess et al, 1925).…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D1 versus ecdysteroids: Growth effects on cell regeneration and malignant growth in insects are similar to those in humans

Sláma¹

2019

Eur. J. Entomol.

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Polyhydroxylated derivatives of 6-keto,7-dehydrocholesterol (ecdysteroids) are common constituents of various plants. In 1965, they were accidentally discovered in the search for the insect moulting hormone. These biologically important natural compounds are neither insect hormones nor inducers of insect ecdysis. Due to their strong anabolic, vitamin D-like effects in insects, domestic animals and humans, I propose the use of the arbitrary term vitamin D 1 . The present paper describes the effects of vitamin D 1 on the growth and regeneration of excised epidermal cells of the tobacco hornworm, Manduca sexta (Sphingidae). The periods of programmed cell death and cell proliferation (histolysis and histogenesis, respectively) exactly coincide in insects with endogenous peaks of increased concentration of vitamin D 1 . Epidermal cells communicate with each other, creating a mutually integrated tissue, connected by mechanical, chemical, electrical, ionic or other so far incompletely known factors. After natural cell death, or after the artifi cial removal of some epidermal cells, the neighbouring cells that lose communication integrity, begin to divide mitotically to replace the disconnected part. Cell divisions are arrested as soon as the integrity of the living tissue is established. During insect ontogeny, the application of juvenile hormone causes regenerating epidermal cells to repeat the previous morphogenetic programme (i.e., development of patches of larval tissue on the body of a pupa, or metathetely). Conversely, the application of vitamin D 1 (20-hydroxyecdysone) caused the regenerating cells to prematurely execute a future morphogenetic programme (i.e., development of patches of pupal tissue on the body of a larva, or prothetely). Among the key features of insect regeneration, is the arrest of cell divisions when tissues resume living cell-to-cell integrity. This prevents the formation of aberrant groups of cells, or tumours. It is well established that the main physiological systems of insects (e.g., circulatory, respiratory, neuro-endocrine) are structurally and functionally similar to corresponding systems in humans. Thus the basic principles of cell regeneration and the role of vitamin D 1 in insects may also be valid for humans. The common vitamins D 2 (ergocalciferol) or D 3 (cholecalciferol), are exclusively lipid soluble secosterols, which require activation by UV irradiation and hydroxylation in the liver. By contrast, the neglected vitamin D 1 is a natural derivative of polyhydroxylated 7-dehydrocholesterol of predominantly plant origin, which is both partly a water and partly a lipid soluble vitamin. It neither requires UV irradiation, nor hydroxylation due to 6 or 7 already built-in hydroxylic groups. Like other vitamins, it enters insect or human bodies in plant food or is produced by intestinal symbionts. Vitamin D 1 causes strong anabolic, vitamin D-like effects in domestic animals and in humans. I am convinced that avitaminosis associated with a defi ciency of vitamin D 1 in human blood may...

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Section: A Brief History Of Vitamin D Researchmentioning

confidence: 99%

Section: History Of Ecdysteroidsmentioning

confidence: 99%

Section: Th E Neglected Role Of Vitamin D 1 In Human Health Carementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Vitamin D1 versus ecdysteroids: Growth effects on cell regeneration and malignant growth in insects are similar to those in humans

Sláma¹

2019

Eur. J. Entomol.

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“…[5] [8] Parallel mit dem Einzug physikalischer Methoden in die Chemie stellten sich für den jungen, nach wissenschaftlicher Unabhängigkeit und Eigenständigkeit strebenden Forscher zunehmend Fragen nach dem "Wie und Warum" chemischen Reaktionsverhaltens, nach den "Mechanismen" chemischer Reaktionsabläufe. Als post-Doktorand in Heidelberg bei dem späteren Nobelpreisträger Karl Ziegler (1931Ϫ1936) fand Lüttringhaus zu den Themen, die aus diesen Interessen resultierten und die ihn ein Leben lang begleiteten: Stereochemie und Metallorganische Chemie.…”

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