Über den immunologischen Nachweis eines sauren α 1-Glykoproteins in in vivo neutralisiertem Magensaft (NMS) von Patienten mit Magencarcinom und metaplastischen Schleimhautveränderungen

Mikulicz-Radecki, Jan; Heim, Markus H.; Rapp, W.

doi:10.1007/978-3-642-85448-4_178

Cited by 2 publications

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“…plasma proteins, especiallyone al-globulin were increased when compared to the normal tissue [7]. The present report-an extension of preliminary studies [5]-describes the immunochemical identification of ~a-acid glycoprotein (AGP) in nGJ of gastric cancer patients by double gel diffusion. The present report-an extension of preliminary studies [5]-describes the immunochemical identification of ~a-acid glycoprotein (AGP) in nGJ of gastric cancer patients by double gel diffusion.…”

Section: ~1-saures Glykoprotein Im Magensaft Yon Patienten Mit Magencmentioning

confidence: 95%

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? 1-Acid glycoprotein in gastric cancer juice

et al. 1975

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Gastric juice was neutralized (nGJ) in vivo by 80 ml of a phosphate buffer containing radiolabelled vitamin B12 as dilution indicator. Unprocessed nGJ was analyzed in the double gel diffusion technique for the presence of serum proteins using monospecific antisera. Alpha1-Acid glycoprotein (AGP) was found in a high incidence (36 out of 38 subjects) in nGJ of gastric cancer patients. AGP was also observed less frequently in nGJ of patients with Billroth II resections (6/15), metaplasia (11/52), gastric ulcer (3/24), chronic atrophic gastritis (2/26) and chronic gastritis (3/63). AGP was absent in the control group (0/21), in patients with surface gastritis (0/38) and in subjects with normal acid secretion (0/45). Immunochemical studies demonstrated no identity of AGP with human "gastrointestinal tumor associated antigens." In 7 out of 17 AGP positive samples immunochemical differences between gastric and serum AGP were observed.

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Section: ~1-saures Glykoprotein Im Magensaft Yon Patienten Mit Magencmentioning

confidence: 95%

“…Quantitative plasma protein determinations were done by the linear gel diffusion method of Oudin as described previously [5] or by the single radial diffusion technique of Mancini using Partigen plates (Behringwerke). The trays were filled with 2.5 ml of 0.75% agarose dissolved in Sod.…”

Section: Immunochemicat Determination Of Plasma Proteins In Ngjmentioning

confidence: 99%