Über den Wirkungsmechanismus des Prontosils

Kollath, Werner; Raabe, Fritz

doi:10.1007/bf01783636

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“…They picture tran sitional stages between reticular cells and plasma cells which they · identify (20,21) with lymphoid cells. To those who consider such cells to be lymphocytes (see p. 162), the data would actually support the lymphocyte theory of antibody fo rmation. The macrophage theory of antibody formation is based upon the reasonable assumption that cells which remove and digest particulate antigen should also form antibodies.…”

Section: Cells Involved In Antibody Formationmentioning

confidence: 56%

The Cellular Basis of Immunity

Taliaferro¹

1949

Annu. Rev. Microbiol.

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Once invading organisms or other antigenic materials have passed or have been introduced beyond the epithelial or mechani cal barriers, their localization and disposal is a part of local (local inflammation) and general defense reactions. The main functional roles of the cells involved in these reactions are (a) to remove foreign material by extra-or intracellular digestion (phagocytosis) or to isolate it by a connective tissue wall (encapsulation); (b) to perform various reparative processes; and (c) to produce specific antibodies. With the exception of that part of repair which involves the parenchyma, the cells involved belong almost exclusively to the connective tissue, especially to the blood and lymph, to the reticular and loose connective tissues, and to the lamina propria and interstitial connective tissues of various organs including the brain. The cells are important to varying degrees in immunity be cause (a) they are ubiquitous in distribution or are easily mobilized via the blood stream; (b) they are phagocytic and/or possess potent digestive enzymes; and (c) they form a mesenchymal reserve in the postnatal vertebrate by retaining varying degrees of their embryonic power to develop into other cells of the connective tissue. These cells have other functions. As a whole, they take part in such diverse processes as intermediate metabolism, storage and mechanical support. A review of the functions of the reticulo endothelial system is given by Jaffe (1) and of the leucocytes by Rebuck (2) The present review stresses work of immediate interest to immunologists. It also outlines briefly the cells involved and their interrelationships because both subjects are fundamental to an understanding of the cellular aspects of immunity. The coverage, as a result, although largely limited to the last 10 years, has been selective, particularly as regards the latter aim, and includes some older work for purposes of orientation. CONNECTIVE TISSUE CELLS INVOLVED IN IMMUNITYThe cells involved in immunity are listed in Table I together with the systems into which they have been incorporated (d. 3) 159 Annu. Rev. Microbiol. 1949.3:159-194. Downloaded from www.annualreviews.org Access provided by University of California -San Diego on 02/03/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS

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Section: Cells Involved In Antibody Formationmentioning

confidence: 56%

The Cellular Basis of Immunity

Taliaferro¹

1949

Annu. Rev. Microbiol.

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Über den Wirkungsmechanismus des Prontosils

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The Cellular Basis of Immunity

The Cellular Basis of Immunity

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