Über den Zusammenhang von Dermatomykosen mit der Penicillin-Überempfindlichkeit

Blum, G; Weck, A.L. de

doi:10.1159/000254369

Cited by 11 publications

(3 citation statements)

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“…It is practically impossible to eliminate all antigenic properties of penicillin by steam sterilization. It should also be remembered that some dermatophytes may produce small quantities of penicillin or penicilloyl antigens and thus initiate penicillin allergy (4).…”

Section: Discussionmentioning

confidence: 99%

Challenge of Penicillin‐Allergic Volunteers with Penicillin‐Contaminated Meat

Lindemayr

Knobler

Baumgartner

1981

Allergy

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In order to obtain information about the clinical course and immunological background of possible allergic reactions due to penicillin-containing food, nine volunteers with penicillin allergy proved by case history, positive skin tests and/or positive penicilloyl-specific RAST were exposed to penicillin-contaminated pork. For this purpose a farm pig from an inbred strain received "therapeutic" doses of benzyl procain penicillin before being slaughtered. Meat samples were taken from muscle tissues, kidney and liver and analyzed by diffusion and extraction methods. Very small amounts of penicillin were detectable in muscle tissue, whereas kidney material contained up to five times as much (0.12 mcg/g). Except two cases which reacted with itchy sensations after ingestion of penicillin contaminated meat "á la tartare", all probands were clinically free of symptoms. Assaying penicilloyl-specific IgE antibodies by RAST during the trial, a tendency to increased levels in the serum after 2 and 24 h was noted, whereas the titers of BPO-specific IgG antibodies measured by the red cell-linked antigen-antiglobulin reaction (RCLAAR) remained unchanged. It is concluded from this study that small and hidden amounts of penicillin and its derivatives in food seldom induce anaphylactic reactions in penicillin allergic patients.

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Section: Discussionmentioning

confidence: 99%

Challenge of Penicillin‐Allergic Volunteers with Penicillin‐Contaminated Meat

Lindemayr

Knobler

Baumgartner

1981

Allergy

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“…Zudem gab ein Großteil dieser Patienten Schmerzen in der Umgebung des befallenen Nagels an, die zum Teil mobilitätslimitierend wirkten [7]. [5,54], wobei jedoch insgesamt keinerlei Untersuchungen existieren, welche die entsprechenden klinischen Auswirkungen dieser Beobachtungen darlegen.…”

Section: Notwendigkeit Der Onychomykosetherapieunclassified

Therapie der Onychomykose

Reisberger

Szeimies²

2000

Med Klin

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Topical urea and bifonazole therapy was available in the past as well as systemic antimycotic therapy with just griseofulvin or ketoconazole. Nowadays a different spectrum of easily applicable, safe and effective therapeutic measures is on the physician's hands. Besides topical therapy with ciclopirox and amorolfine oral treatment with itraconazole, terbinafine and fluconazole is available. Combination therapy of terbinafine orally in addition with topical application of ciclopirox may possibly optimize the therapeutic approach considering the respective response rates however, no clinical study evaluating this hypothesis has been performed so far.

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“…On the one hand detection of such persons is improved bymore sensitivetesting methods. On the other hand the general population is brought increasingly into contact with penicillin, either by penicillin-contaminated food or by infection with penicillin-producing dermatophytes (G6tz, 1962;Blum and de Weck, 1966).…”

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confidence: 99%