Über die Beziehung der Plasmazellen im Liquor zur Aktivität der multiplen Sklerose

Bammer, Hans

doi:10.1007/978-3-642-96034-5_118

Cited by 1 publication

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Correlations between pleiocytosis and increased levels of IgG in the CSF of MS patients are well known (1, 25,31,34,35). We show in this paper that there is a correlation between these CSF alterations and the presence of plasma cells in CSF (Tables 2 and 4), a fact which has only been suggested to date (2,13,15, 23,24,36). This is a further argument for the local synthesis theory of IgG in MS (31) and, even more, for an IgG production by CSF circulating lymphoid cells.…”

Section: Discussionsupporting

confidence: 68%

“…In 1939, Voss (21) reported the presence of plasma cells in MS CSF. This was widely confirmed (2,5,13,14, [22][23][24][25][26][27][28][29][30]. Only Tourtelotte (31) holds the opinion that plasma cells represent 0.3% of the total cells in normal CSF and that their ratio is not modified in MS patient CSF.…”

Section: Discussionmentioning

confidence: 87%

“…Several authors (2, 23,28) have noted that plasma cells in CSF were more frequently observed or more numerous during exacerbations in comparison to remission or progression of the disease. This probably reflected cases with tardive progressive spastic paraplegias.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Plasma cells in cerebrospinal fluid and multiple sclerosis: diagnostic yield and clinicobiological correlations

Confavreux¹,

Caudie²,

Touraine³

et al. 1986

Acta Neurologica Scandinavica

View full text Add to dashboard Cite

Cerebrospinal fluid (CSF) cytocentrifugation was performed for plasma cells' demonstration in parallel with white cell count (WCC) and quantitative protein assays. Over a 5-year period, 154 consecutive multiple sclerosis (MS) patients were studied and compared to 28 other inflammatory neurological disease, 85 non-inflammatory neurological disease and 29 non-neurological disease cases. CSF cytology was easy to perform, gave definitive results within 2 h and was abnormal in 80 MS patients, 26 of whom had a normal WCC. Its sensitivity in MS was 0.57, i.e. higher than for WCC (0.45) but lower than for IgG index (0.70) and IgG synthesis rate (0.71). Its specificity was 0.86, not significantly different from specificity of WCC, IgG index and IgG synthesis rate. Plasma cells demonstration in MS CSF was neither a disease activity nor a prognosis marker. It was significantly correlated with pleiocytosis and intrathecal IgG synthesis. If these morphologically defined plasma cells are actual B cells, they could represent circulating individuals of the lymphocyte clones active in MS plaques and have a pathogenetic significance.

show abstract

Section: Discussionsupporting

confidence: 68%