Über die erhöhte Tumorhäufigkeit nach Inhalation von Poly-2-vinylpyridin-N-Oxid

Weller, W.

doi:10.1007/bf02047461

“…Other properties may be less favorable, e.g., the anticoagulant effect (heparin, dextran sulfate, polyanethol sulfonate, Liquoid). Extensive toxicological studies will be necessary which have to include the question of carcinogenesis, markedly present in PVPNO (13,14). bOptical density (filter 580); averages ±SE.…”

Section: Commentsmentioning

confidence: 99%

Modification of Biological Surface Activity of Particles

Schnitzer¹

1974

Environmental Health Perspectives

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. The National Institute of Environmental Health Sciences (NIEHS) andBrogan & Partners are collaborating with JSTOR to digitize, preserve and extend access to Environmental Health Perspectives.The hemolytic activity of fibrous asbestos varieties and of fibrous or granular silica dust can be markedly reduced by adsorption of polymers. Polyanions exert a specific action on asbestos, particularly chrysotile, whereas silica is inactivated by nonionic polymers. A high degree of reduction of the lytic action by comparatively small amounts of the antagonistic polymers can be demonstrated after short exposure to concentrations of 0.1-0.4 mg/ml of appropriate polymers. Inactivation is based on stable adsorption. Repeated washings of inactivated mineral sediments or exposure to elevated temperatures (80-120?C) produced no essential loss of the reduction of lytic potency. In one example, inactivation of chrysotile by sodium alginate, depolymerization by ascorbic acid was also ineffective.

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“…However, firstly the total dose of about 3000 mg which was administered was much higher than the 140 mg injected in the study of the effect on quartz carcinogenesis (Pott et al 1994), and secondly tumours were found only in the region of the subcutaneous injection site and not in the lungs. Likewise, the observation that 7 of 115 animals developed lung adenomas or atypical lung tumours after inhalation of high PVNO concentrations (Weller 1971) cannot explain a PVNO-induced lung tumour formation after subcutaneous injection of the substance. Therefore it must be assumed that under the conditions in this experiment, the PVNO treatment affected the development of fibrosis but not the tumour formation.…”

Section: Intratracheal Administrationmentioning

confidence: 98%

Silica, crystalline: quartz dust, cristobalite dust and tridymite dust (respirable fraction) [MAK Value Documentation, 2000]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 14 (2000) The article contains sections titled: Characterization of the substance Chemical and physical properties Occurrence Uses Exposure Exposure situation Sampling and analysis Exposure determination in epidemiological studies Toxic Effects and Mode of Action Toxicokinetics and Metabolism Effects in Man Genotoxicity Carcinogenic effects Non‐malignant effects Animal Experiments and in vitro Studies Genotoxicity Carcinogenicity Manifesto (MAK value/classification)

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“…Other properties may be less favorable, e.g., the anticoagulant effect (heparin, dextran sulfate, polyanethol sulfonate, Liquoid). Extensive toxicological studies will be necessary which have to include the question of carcinogenesis, markedly present in PVPNO (13,14).…”

Section: Commentsmentioning

confidence: 99%

Modification of biological surface activity of particles

Schnitzer¹

1974

Environ Health Perspect

15

0

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The hemolytic activity of fibrous asbestos varieties and of fibrous or granular silica dust can be markedly reduced by adsorption of polymers. Polyanions exert a specific action on asbestos, particularly chrysotile, whereas silica is inactivated by nonionic polymers. A high degree of reduction of the lytic action by comparatively small amounts of the antagonistic polymers can be demonstrated after short exposure to concentrations of 0.1-0.4 mg/ml of appropriate polymers. Inactivation is based on stable adsorption. Repeated washings of inactivated mineral sediments or exposure to elevated temperatures (80-1200C) produced no essential loss of the reduction of lytic potency. In one example, inactivation of chrysotile by sodium alginate, depolymerization by ascorbic acid was also ineffective.

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Über die erhöhte Tumorhäufigkeit nach Inhalation von Poly-2-vinylpyridin-N-Oxid

Cited by 11 publications

References 16 publications

Modification of Biological Surface Activity of Particles

Modification of Biological Surface Activity of Particles

Silica, crystalline: quartz dust, cristobalite dust and tridymite dust (respirable fraction) [MAK Value Documentation, 2000]

Modification of biological surface activity of particles

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