Über Die Morphologie Der Neurosekretorischen Verknüpfung Von Hypothalamus Und Neurohypophyse

Bargmann, W.; Hild, Walther

doi:10.1159/000140414

Cited by 117 publications

(46 citation statements)

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“…The results of the numerous investigations on the first appearances of gomori-positive material in the hypothalamo-neurohypophysial system (Bargmann, 1949;Dawson, 1953;Benirschke & McKay, 1953;Scharrer, 1954;Diepen, Engelhardt & Smith-Agreda, 1954;Green & van Breemen, 1955;Rodeck & Caesar, 1956;Rodeck, 1958;Amoroso, Harrison, Harrison-Matthews, Rowlands, Bourne & Sloper, 1958) can be summarized as follows. At birth the neurosecretory material is scanty in those forms which are also immature by other criteria.…”

Section: Discussionmentioning

confidence: 99%

Maturation of the hypothalamo‐neurohypophysial system

Heller¹,

Lederis²

1959

The Journal of Physiology

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Section: Discussionmentioning

confidence: 99%

Maturation of the hypothalamo‐neurohypophysial system

Heller¹,

Lederis²

1959

The Journal of Physiology

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“…The position of the tip of the cannula, within the SON, was confirmed by the following methods: 1) functionally, by the appearance of an antidiuresis by the injection of depolarizing doses of KC1 (800 nmol) into the SON through the cannula and 2) histochemically, by the locali zation of the site of the tip of the cannula in a group of magnocellular cells in the SON, positively stained by the method of Gomori (25).…”

Section: Identification Of the Sites Of Cannula Insertionmentioning

confidence: 99%

Blockade of Retinal NMDA Receptors by Sodium Nitroprusside Is Probably Due to Nitric Oxide Formation

Ujihara

Akaike

Tsutsumi

et al. 1993

Japanese Journal of Pharmacology

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ABSTRACT-The effects of injection of substance P (SP) into the hypothalamic supraoptic vasopres sinergic nucleus (SON) in water-loaded and ethanol-anesthetized rats were examined. Keywords:Substance P, Antidiuresis, Supraoptic nucleus, Vasopressin, Substance P antagonist Substance P (SP), a member of the tachykinin family of bioactive peptides, is suggested to be a neurotransmit ter or a neuromodulator in the central and peripheral nervous system (1 3). Immunohistochemical studies have shown that SP terminals are found not only in the spinal cord (4) and the substantia nigra (5), but also in the hypothalamus (6, 7). Therefore, the involvement of SP in physiological functions in the hypothalamus such as stimulation of arginine-vasopressin (AVP), growth hor mone and prolactin release has been suggested (8 10).The hypothalamic supraoptic nucleus (SON), as well as the paraventricular nucleus (PVN), contains cell bodies of vasopressinergic neurons that synthesize and release AVP. Stimulation of vasopressinergic neurons by neuro transmitters and neuromodulators induces a release of AVP, eventually causing antidiuresis through the renal AVP (V2) receptors (11,12). By injecting various drugs into the SON or PVN, we have previously shown that cholinergic (13,14), adrenergic (15, 16) and enkephaliner gic mechanisms (17, 18) may control the urine outflow through a stimulation of AVP release.The vasopressinergic cell bodies in the SON or PVN make synaptic contact with SP-containing nerve termi nals (6). It was demonstrated that intraventricular injec tion of SP induced a prolonged antidiuresis in water-load ed rat (19) and an increase in firing frequency of the SON (20). However, the effect of SP microinjected directly into the vasopressinergic nuclei on the AVP release remains un clear. In this study, we examined the effects of SP and its analog [D-Pro2, D-Trp'°9]SP on the outflow, osmotic pres sure and AVP level of urine by injection into the SON in water-loaded and ethanol-anesthetized rats. The influ ences of pretreatments with AVP-receptor, SP-receptor and muscarinic receptor antagonists on the SP-induced antidiuresis were also examined. The present data showed that SP causes antidiuresis through the release of AVP. MATERIALS AND METHODS Animals and drugsMale Wistar rats, weighing 280-330 g, were used.

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“…Identification of the sites of inserted cannula: The position of the tip of the cannula inserted stereotaxically into the SON or PVN was confirmed by the following methods: 1) functionally, by the appearance of the anti diuretic effect by microinjecting a depolarizing dose (400 or 800 nmol) of KCI through the cannula and 2) histochemically, by the localization of the tip of the cannula in a group of magnocellular cells in the SON or PVN which were positively stained by the method of Gomori (23).…”

mentioning

confidence: 99%

Antidiuretic Effects of Methionine-Enkephalin and 2-D-Alanine-5-Methionine-Enkephalinamide Microinjected into the Hypothalamic Supraoptic and Paraventricular Nuclei in a Water-Loaded and Ethanol-Anesthetized Rat

Tsushima

Mori

Matsuda

1986

Japanese Journal of Pharmacology

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Abstract-Effects of methionine-enkephalin (ME) and 2-D-alanine-5-methionine enkephalinamide (DAMEA) microinjected into the hypothalamic supraoptic (SON) and paraventricular (PVN) nuclei, which contain neurons synthesizing and releasing antidiuretic hormone, upon the outflow and the osmotic pressure of urine and the other visceral functions were studied in a rat which was loaded with water and anesthetized with ethanol. These opioid peptides when microinjected into the SON or PVN induced potent antidiuretic effects in dose-dependent and time dependent manners with no significant effects on the other visceral functions. The approx. ED50 values for DAMEA were 1.3 (in the SON) and 0.7 (in the PVN) nmol, and the values for ME were 110 (in the SON) and 60 (in the PVN) nmol. The antidiuretic effects showed slow onset and long duration, with a minimal urine outflow at approx. 0.5 hr after microinjection and an approx. 2 hr-duration. The effects induced by the opioid peptides were inhibited by pretreatment with naloxone or atropine, without effects of pretreatment with alpha or beta-adrenoceptor antagonists, suggesting that the antidiuretic effects were mediated through an opioid receptor having low sensitivity to naloxone and also possibly mediated through a muscarinic receptor which was stimulated probably by the ACh released by the opioid peptides.

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Über Die Morphologie Der Neurosekretorischen Verknüpfung Von Hypothalamus Und Neurohypophyse

Cited by 117 publications

References 0 publications

Maturation of the hypothalamo‐neurohypophysial system

Maturation of the hypothalamo‐neurohypophysial system

Blockade of Retinal NMDA Receptors by Sodium Nitroprusside Is Probably Due to Nitric Oxide Formation

Antidiuretic Effects of Methionine-Enkephalin and 2-D-Alanine-5-Methionine-Enkephalinamide Microinjected into the Hypothalamic Supraoptic and Paraventricular Nuclei in a Water-Loaded and Ethanol-Anesthetized Rat

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