Über die Ovarialfunktion nach Uterusexstirpation

Baidin, Alexander

doi:10.1007/bf01751182

Cited by 6 publications

(1 citation statement)

References 10 publications

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“…Apart from the changes that occur soon after operation, it has been shown that hysterectomy leads eventually to ovarian degeneration involving increased follicular atresia in the rat (see Spumy, 1959) and some other species, e.g. mouse (Hall, 1934), rabbit (Sessums & Murphy, 1933;Mishell & Motyloff, 1941;Tenney, Parker & Robbins, 1958), dog (Cheval, 1934(Cheval, , 1935) and cat (Baidin, 1939). These long-term effects have been revealed during investiga¬ tions conducted with particular reference to the occurrence of ovarian cysts in women after hysterectomy (see Reynolds, 1949), and they have not been related to the more immediate effects on the ovarian cycle except by Sessums & Murphy and Mishell & Motyloff {loc.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hysterectomy on the Ovarian Cycle of the Rat

Perry¹,

Rowlands²

1961

Reproduction

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The normal periodicity of the dioestrous cycle of the un¬ mated rat was not permanently altered by hysterectomy, but when the operation was performed during or shortly after oestrus, the dioestrous interval was prolonged to a variable extent. The average duration of this period was longer than that of pseudopregnancy, but the vaginal smear and ovarian changes were very similar in both conditions. Subsequent dioestrous cycles were of normal length (4 to 5 days). The effect of hysterectomy on the current cycle probably resulted from cervical stimulation during the operation. Hysterectomy after sterile mating caused a similar prolongation of the current cycle and all subse¬ quent cycles of pseudopregnancy in the hysterectomized rat. No ovarian degeneration was observed in rats killed up to 4 months after hysterec¬ tomy. Interspecific differences in the ovarian response to hysterectomy are briefly discussed.

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Section: Introductionmentioning

confidence: 99%

Effect of Hysterectomy on the Ovarian Cycle of the Rat

Perry¹,

Rowlands²

1961

Reproduction

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Local uterine regulation of the corpus luteum

Fischer

1967

Am. J. Anat.

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In order to determine if the well known uterine inhibition of the guinea pig corpus luteum is a local effect, a series of partial hysterectomies were performed. Some groups were subjected to one-half or three-fourths hysterectomies alone, while in others one ovary was also removed on either the side retaining some or the side losing all uterine tissue. In addition, two groups in which all ovarian and uterine tissue was preserved were subjected to unilateral or bilateral complete surgical separation of all communicating structures between uterus and ovary. Sham-operated, totally hysterectomized, and unilaterally ovariectomized groups were used as controls.In all groups in which an ovary left in the animal was separated from direct contact with its uterine horn, the estrous cycles became long and erratic, or were arrested completely due to the persistance of active corpora lutea in those ovaries. However, corpora lutea regressed normally in all ovaries left in their normal relationship to a uterine horn. These results indicate that the uterine regulatory factor does reach the ovary by some local route.The mammalian uterus has, since ancient times, been known as the organ in which the young undergo embryonic development, yet only within the last 45 years has it been suspected of playing a more subtle role in the physiology of reproduction. Experiments conducted by Loeb (' 23, '27) upon the guinea pig demonstrated that, in at least this one form, the uterus is capable of contributing to the regular cyclic rhythmicity of the ovary by periodically curtailing the functional life of the corpus luteum. Loeb found that removal of the uterus a few days after estrus resulted in a sudden and complete cessation of all cyclic activity for a period much longer than the normal duration of pregnancy. The corpora lutea in these anestrous animals were evidently in a state of high activity; they were larger than those of pregnancy, and were composed of large polygonal cells, many of which were in mitosis.Histological examination of the vagina and mammary glands gave additional evidence that the corpora lutea were actively secreting progesterone. Since Loeb's work, this phenomenon in the guinea pig has been amply confirmed by many others, and has been proven to exist in other mammals. In all cases where hysterectomy provokes a disruption of the sexual cycle, the corpus luteum is maintained in an apparently functional state. AM. J. ANAT., 121: 425-442.Loeb's experiments quickly stimulated interest in the field of utero-ovarian relationships. Studies were made of many different mammals to determine whether the effect of hysterectomy was of a more general occurrence. In recent years, it has also been found that distension of the uterus results in the opposite phenomenon, the early regression of corpora lutea and concomitant shortening of the estrous cycle (Moore and Nalbandov, '53). The results of the various types of experiments performed during these years fall into three main groups. No apparent uterine influence onthe ovary ...

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Der Einfluß des Uterus auf die Entwicklung experimenteller Ovarialtumoren

Gitsch¹,

Holzner²

1969

Siebenunddreissigste Versammlung Abgehalten Zu Lübeck-Travemünde Vom 24. Bis 28. September 1968

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Über die Ovarialfunktion nach Uterusexstirpation

Cited by 6 publications

References 10 publications

Effect of Hysterectomy on the Ovarian Cycle of the Rat

Effect of Hysterectomy on the Ovarian Cycle of the Rat

Local uterine regulation of the corpus luteum

Der Einfluß des Uterus auf die Entwicklung experimenteller Ovarialtumoren

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