Über die Parathyreotrope Wirkung von Hypophysenvorderlappenextrakten

Anselmino, K. J.; Hoffmann, Fr.; Herold, L.

doi:10.1007/bf01799042

Cited by 31 publications

(3 citation statements)

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“…T h e p ro b a b ility o f a p itu ita r y influence received stro n g su p p o rt fro m th e an im al e x p e rim e n ts o f A nselm ino et al [29] a n d o th e r in v e stig a to rs. T h ese a u th o rs o b ta in e d a sy ste m a tic h y p e rp la sia o f th e p a ra th y ro id g lan d s in dogs an d ra ts b y th e a d m in istra tio n o f an ex tr a c t o f th e a n te rio r lobe o f th e p itu ita ry gland.…”

Section: Discussionmentioning

confidence: 99%

Pluriglandular Syndrome

Berdjis¹

1962

Oncology

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Section: Discussionmentioning

confidence: 99%

Pluriglandular Syndrome

Berdjis¹

1962

Oncology

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“…These were weakness, dizziness, headaches, easy fatigability, drowsiness, increased appetite and constipation. Enlargement of the hands and feet was first noticed 4 Roentgenograms showed definite enlargement of the sella turcica with some erosion of the clinoid processes, enlarged sinuses, hypertrophy of the mandible, separation of the teeth, tufting of the terminal phalanges and broad metacarpals.…”

Section: Protocolsmentioning

confidence: 99%

“…In 1934 Hertz and Kranes (3) and Anselmino, Hoffnann and Herold (4) found that injections of an alkaline extract of the anterior pituitary gland into rabbits and rats caused hypertrophy of their parathyroid glands. Marenzi and Gerschman (5), working with dogs, were unable to demonstrate such an effect regularly.…”

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confidence: 99%

Studies of Calcium and Phosphorus Metabolism. Xvi. The Influence of the Pituitary Gland 1

Bauer

Aub²

1941

J. Clin. Invest.

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The literature pertaining to the effects of the anterior pituitary gland on calcium and phosphorus metabolism, well summarized by Zwarenstein (1) and Houssay (2), is meager and the results reported are contradictory. This is due in part to the fact that many of the previous workers employed inert anterior pituitary gland preparations.In 1934 Hertz and Kranes (3) and Anselmino, Hoffnann and Herold (4) found that injections of an alkaline extract of the anterior pituitary gland into rabbits and rats caused hypertrophy of their parathyroid glands. Marenzi and Gerschman (5), working with dogs, were unable to demonstrate such an effect regularly.Alterations in the blood calcium have rarely been observed following either hypophysectomy or the administration of anterior pituitary gland extracts. Hogben (6) did report the occurrence of a low blood calcium in the toad (Xenopus Laevi) following removal of the anterior pituitary and the pars intermedia. He further stated that injections of pituitary extracts caused a fall in the blood calcium. These observations have been confirmed by Shapiro and Zwarenstein (7).The evidence suggesting that the pituitary influences the parathyroid glands and calcium and phosphorus metabolism in higher animals is even more conflicting. Gerschman and Marenzi (8), working in Houssay's laboratory, found no change in the blood calcium of hypophysectomized dogs but did observe an elevation following the administration of an alkaline anterior pituitary extract, a finding previously noted in one dog by Thompson and Cushing (9). Subsequently, Marenzi and Gerschman (10) reported that such extracts were without effect on the blood calcium of four thyroparathyroidectomized dogs. Because of the 1 The expenses of this investigation were aided in part by a grant from the Commonwealth Fund.extreme difficulty in maintaining such experimental animals in a constant state, too much significance cannot be attached to these results. Friedgood (11) and Friedgood and McLean (12) noted increased blood calcium levels in rats and guinea pigs when alkaline anterior pituitary extracts were given. A tendency to a negative calcium balance in hypophysectomized rats, counteracted by injections of growth-promoting pituitary extracts, was observed by Pugsley and Anderson (13).The literature may be summarized as follows: Injections of alkaline anterior pituitary extracts produce hypertrophy of the parathyroid glands and may cause elevation of the blood calcium level. It has not been definitely proved that this latter effect is lost in the absence of the thyroid and parathyroid glands. Hypophysectomy does not alter the blood calcium level of animals other than the toad.The evidence favoring a relationship of the pituitary to the parathyroid glands and calcium and phosphorus metabolism in man consists of histological material collected by Cushing and Davidoff (14) and metabolism studies on two acromegalic patients (15, 16). Scriver and Bryan (15) studied a case of acromegaly with marked osteoporosis. Although they demonstrat...

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Diseases of Metabolism and Nutrition

Wilder¹

1939

Arch Intern Med (Chic)

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Über die Parathyreotrope Wirkung von Hypophysenvorderlappenextrakten

Cited by 31 publications

References 8 publications

Pluriglandular Syndrome

Pluriglandular Syndrome

Studies of Calcium and Phosphorus Metabolism. Xvi. The Influence of the Pituitary Gland 1

Diseases of Metabolism and Nutrition

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