Über die reine Mediaverkalkung der Extremitätenarterien und ihr Verhalten zur Arteriosklerose

Mönckeberg, J. G.

doi:10.1007/bf01926946

Cited by 228 publications

(88 citation statements)

References 2 publications

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“…In blood vessels, calcified deposits are found in distinct layers of the blood vessel and are related to underlying pathology. Intimal calcification occurs in atherosclerotic lesions (1,2), whereas medial calcification (also known as Monckeberg's medial sclerosis) is associated with vascular stiffening and arteriosclerosis observed with age, diabetes, and ESRD (3,4). Intimal calcification may occur independently of medial calcification and vice versa.…”

mentioning

confidence: 99%

Vascular Calcification Mechanisms

Giachelli

2004

Journal of the American Society of Nephrology

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confidence: 99%

Vascular Calcification Mechanisms

Giachelli

2004

Journal of the American Society of Nephrology

497

400

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“…Several subsequent authors agree. 4,11,17 However, others maintain that Mönckeberg's sclerosis does involve the internal elastic lamina. Our recent study (Archives of Pathology and Laboratory Medicine, in press) found that Mönckeberg's sclerosis involved both the media and internal elastic lamina with calcification in all 14 of the arterial specimens we reviewed.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Intimal calcification is found in large arteries, including the coronaries, and is associated with atherosclerotic plaques. Medial calcification, first described by Mö nckeberg, 4 is independent of atherosclerosis and is seen primarily in the media of muscular arteries of the extremities and only rarely in the visceral or coronary arteries. There is, however, a third pattern of calcification that appears to be distinct from both intimal and medial calcification and which has received far less attention-that is, calcification limited to the internal elastic lamina.…”

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confidence: 99%

Calcification of the internal elastic lamina of coronary arteries

et al. 2008

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Two well-recognized patterns of calcification occur in large-and medium-sized arteries, intimal calcification associated with atherosclerosis and medial calcification described by Mö nckeberg. Calcification limited to the internal elastic lamina is a third pattern of calcification not previously reported in coronary arteries. Here we describe 19 cases of coronary artery internal elastic lamina calcification. We serially sectioned and examined the coronary arteries of 66 patients with advanced AIDS and 27 HIVÀ controls with other chronic illnesses. We observed calcification of the internal elastic lamina in 10 HIV þ patients and 9 controls. HIVÀ patients with internal elastic lamina calcification were significantly older than HIVÀ patients without it (P ¼ 0.008) and HIV þ patients with it (P ¼ 0.006). Occasionally, calcification encroached on adjacent intimal or medial tissue with mild fibrosis. There was frequent disruption of the internal elastic lamina but no evidence of inflammation. Calcification was the dominant histologic feature in all cases. Von Kossa, Alizarin red, and trichrome/elastic stains confirmed these findings. Patients with internal elastic lamina calcification often had extensive medical histories but did not suffer from chronic renal failure or other conditions known to cause calcium dysregulation. We describe coronary internal elastic lamina calcification in HIV þ patients and older HIVÀ adults. The clinical significance of this finding is unknown. It could lead to arterial stiffening and increased pulse pressure and could be mistaken for intimal calcification on coronary imaging. Internal elastic lamina calcification may result from premature aging due to HIV disease and chronic illness or from metabolic disorders in HIV þ patients.

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“…En un estudio de pacientes que fallecieron por causa cardíaca, las lesiones de placa coronaria fueron categorizadas según clasificación de Stary 19 , observándose que las placas coronarias de los sujetos con ERC eran predominantemente tipo VII (intensamente calcificadas), en una magnitud 4 veces superior a lo encontrado en los pacientes sin ERC 20 . Mönckeberg describió la presencia, en arterias periféricas, de una calcificación vascular que ocurría en la túnica media vascular, generalmente en la lámina elástica interna y que no se asociaba a macrógafos cargados de lípidos o hiperplasia intimal 21,22 . Este tipo de calcificación y la que ocurre en la placa ateroesclerótica son muy comunes en la ERC avanzada y pueden coexistir en un mismo vaso 23 .…”

Section: Calcificación Vascularunclassified