Über die Schafferschen Magenschleimhaut-inseln der Speiseröhre

Schwalbe, K.; Lubarsch,

doi:10.1007/bf02029812

Cited by 13 publications

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“…They observed that fragmentation was increased in anemia and also by such mechanical factors as pressure and heat. The process had been seen by many observers; for example, by Ehrlich (3), Arnold (4), Schwalbe (3,6), Max]mow (7), Weidenreich (8), and others, with varying interpretations, but it was Rous and Robertson who determined that it is a constant and, in their judgment, the major factor in the destruction of red cells.…”

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Normal and Pathological Fragmentation of Red Blood Cells; The Phagocytosis of These Fragments by Desquamated Endothelial Cells of the Blood Stream; The Correlation of the Peroxidase Reaction With Phagocytosis in Mononuclear Cells

Doan

Sabin

1926

Journal of Experimental Medicine

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In 1917, Rous and Robertson (1, 2) demonstrated that there is a constant fragmentation of red cells in the circulating blood of the normal animal. They drew blood directly from the hearts of mammals into gelatin-Locke-citrate and obtained microcytes and poikilocytes by differential centrifugation. They observed that fragmentation was increased in anemia and also by such mechanical factors as pressure and heat. The process had been seen by many observers; for example, by Ehrlich (3), Arnold (4), Schwalbe (3, 6), Max]mow (7), Weidenreich (8), and others, with varying interpretations, but it was Rous and Robertson who determined that it is a constant and, in their judgment, the major factor in the destruction of red cells.We have been able to confirm the concept that there is a constant fragmentation of red ceils in the circulation of the normal rabbit by the study of films of fresh blood, and have found that the fate of these fragments is to be taken up by the so called clasmatoeytes or wandering endothelial phagocytes. We shall use the three terms: clasmatocyte, wandering endothelial phagocyte, and macrophage as synonymous and distinct from monocyte. Clasmatocytes with fragments of red cells are to be found in the circulating blood, in the spleen, and in the connective tissues, and we think that they can be discriminated, when studied with the supravital technique, from eosinophilic leucocytes, with which they have been confused in the literature. Thus,

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confidence: 99%