Über die Verteilung und die Aktivität hydrolytischer Enzyme in der Epidermis klinisch gesunder Psoriatikerhaut

Fifty-two biopsies from involved and clinically normal looking skin of patients with psoriasis vulgaris and from normal control subjects, all being treated with 8-MOP-UVA (PUVA) were obtained between days 2 and 300. The following parameters were investigated: 1. initial PUVA effects; 2. initial regression of psoriasis under PUVA-therapy; 3. late effects of PUVA-therapy on regression of psoriatic lesions; 4. EFFects on melanocytes and pigmentation; and 5. long-term effects of PUVA-therapy. Paraffin embedded and cryostat sections were prepared with routine stains for light microscopy and enzyme histochemical special stains. The regression of psoriatic lesions following PUVA-therapy was separately assessed for epidermal and dermal components. The sequence of events was as follows: re-establishment of a continous stratum granulosum, re-establishment of a continuous normal appearing stratum corneum, regression of acanthosis and papillomatosis, and regression of inflammatory infiltration. During the initial phase of PUVA-therapy there is a sharp increase of melanocytes which leads to a foamy appearance of the basal cell area. Long term studies did not reveal actinic damage of the skin, neither in the epidermis (absence of actinic keratoses or squamous cell carcinomas) nor in the dermis (absence of actinic "solar" elastosis).

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Percutaneous Absorption of Salicylates from Some Commercially Available Topical Products Containing Methyl Salicylate or Salicylate Salts in Rats

Megwa

Benson

Roberts

1995

Journal of Pharmacy and Pharmacology

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Studies to determine the extent of local tissue penetration of topically applied, commercially available salicylate esters and salts were conducted in male Wistar rats. The salicylate concentration in plasma, tissues underlying the site of drug application, and similar tissues on the contralateral (control) side were measured. The plasma and tissue salicylate levels suggest that direct penetration of salicylate was predominant to the top muscle level on the treated site. Results also suggest that the drugs were first absorbed into the bloodstream and subsequently distributed to both the deeper tissues on the treated site and the contralateral tissues. The topical application of formulations of ester methyl salicylate and salts triethanolamine salicylate and diethylamine salicylate containing comparable salicylate concentrations yielded similar salicylate concentrations in the various tissues. The salicylate concentrations in the deeper tissues approached concentrations observed in the contralateral tissues suggesting that salicylate present in these tissues was due to the systemic blood supply.

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Über die Verteilung und die Aktivität hydrolytischer Enzyme in der Epidermis klinisch gesunder Psoriatikerhaut

Cited by 5 publications

References 10 publications

Cytochemical examinations of cultivated epidermis cells of clinically healthy psoriatic skin

Cytochemical examinations of cultivated epidermis cells of clinically healthy psoriatic skin

Feingewebliche Ver�nderungen unter Photochemotherapie der Psoriasis

Percutaneous Absorption of Salicylates from Some Commercially Available Topical Products Containing Methyl Salicylate or Salicylate Salts in Rats

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