Ten healthy male subjects received an infusion of 10 % maltose solution at a rate of 0.5 g/kg body weight/h for 345 min. Blood maltose levels rose continuously for the first hours; after 285 min a constant level was maintained. Concomitantly increasing maltosuria occurred; the total renal maltose excretion averaged 30.4 % of the administered dose. In addition to maltose losses, considerable glucosuria (up to 16 % of total carbohydrate excretion) was found. The glucosuria occurred in spite of normal blood glucose levels. Serum insulin did not rise during maltose infusion. In the majority of cases, glucose is the carbohydrate of choice for parenteral nutrition (6, 10). Nevertheless, other sugars need to be studied. Maltose, a disaccharide consisting only of glucose, is currently attracting attention. There is evidence that intravenous maltose is metabolized in man (9, 12, 13); however, data on the degree of the utilization of maltose are lacking. We report blood level, urinary excretion and utilization of maltose in healthy subjects during maltose infusion. Blood glucose, serum insulin, and urinary glucose excretion were also studied.