“…The very great selectivity of K+ over Na+ response ( 3-104) has made these electrodes useful in situations where glass electrodes fail, particularly in analyses of biological fluids. Examples include K+ determination in rat kidney tubules (475), blood plasma or serum (630, 758,1017) and simultaneous Na+ and K+ activity measurement (954). Other applications include KC1 activity measurements (ISO), potassium adenosine triphosphate equilibria studies (791), soil analyses (40), and potassium uptake by cells (844) The details of the mechanism of potential development in neutral carrier is still difficult to explain except for exceedingly thin bilayer membranes which can be interpreted by Eisenman and coworkers' space charge model (243).…”