Über Kurchi‐Alkaloide, III. Neue Basen aus Kurchirinde

Abstract

Es wird die lsolierung von zwei Monomethyl-holarrhiminen und von Tetramethyl-holarrhimin aus der Rinde beschrieben sowie Uber ein neues Alkaloid Kurchamin berichtet, fdr das die Konstitution eines 5.6-Dihydro-(20)-N-methylconkurchins angenommen wird. R I 1. Conarrhimin-Typ = Conkurchin-Typ 11. mit Doppelbindung

Steroidal Alkaloids From the Apocynaceae Family: Their Isolation and Biological Activity

“…revealed N-demethylmitiphylline (72) and mitiphylline (73), 100,101 and N 3 -methylholarrhimine (74), holarrhimine (75), and 4 were obtained from the bark. 70,102 The alkaloid 74 was also reported in the bark of H pubescens (Apocynaceae) 84 while 75 was found in the bark of H pubescens (Apocynaceae) 78,81 and in an unstated part of W. arborea (Apocynaceae). 72 Phytochemical studies on the seed extract of H pubescens (Buch.…”

“…10,12,13,16,17,23,27,31,44,[66][67][68][69][70][71][72][73] The pregnane steroidal alkaloids (eg, 22, 23, 25, 27, 28, 32, 35, 37, and 38) were also found in the genera Pachysandra, Sarcacocoa, and Buxus of the Buxaceae and the genera Chonemorpha, Holarrhena, Funtumia, Malouetia, and Wrightia (Table 1). 21,23,24,31,49,58,59,62,64,65,70,72,[74][75][76][77][78][79][80][81][82][83][84] In contrast, the alkaloids 12, 13, 16, 18, 19 to 21, 24, 26, 33, and 36 were only found in the genus Funtumia.…”

“…31,75,105 The roots of H pubescens yielded holacetine N 20 -methylholarrhimine (111), holarrhidine (112), kurchimine (113), dihydroisoconessimine (114), holacine (115), holacimine, holarrifine (116), kurchinidine (117), kurchinine (118), pubescine (119), norholadiene (120), pubescimine (121), holamide (122), pubescinine (123), pubamide (124), norkurchamide (125), pubatriol (126), mokluangin B (127), mokluangin C (128), 7α-hydroxyconessine (129), and 3, 4, 77, and 90 were found in the bark of H pubescens. 11,13,18,22,27,68,78,81,84,97,[111][112][113][114][115][116][117][118][119] Holarrhine was previously isolated from H pubescens. 116 The structures of holacimine and holarrhine remain unknown.…”