Key words Foundations of quantum physics, wave-particle duality, quantum entanglement, mesoscopic quantum physics, quantum-classical transition. PACS 03.65.-w, 03.65.Ta, 03.65.Ud, 03.65.Yz, 03.67.-a, 03.67.Mn This paper is dedicated to Prof. Paolo Tombesi on the occasion of his 70th birthday.Modern experimental developments allow to address the fundamental challenges of quantum physics on new, macroscopic scales. How far can such experiments be pushed with current technology? We discuss three specific examples, long-distance photonic entanglement, matter wave interferometry and superposition states of mechanical resonators, and discuss possible extensions to these experiments. It turns out that there is "plenty of room at the top" for macroscopic quantum experiments, even with presently available technology.