Über Oxydation von Komplexverbindungen des Platins. Abhandlung I. Oxydation durch Wasserstoffsuperoxyd und Ozon

Tschugajeff, L.; Chlopin, Witalius; Fritzmann, E.

doi:10.1002/zaac.19261510125

Cited by 14 publications

(7 citation statements)

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“…The compounds c,c,t -[Pt(NH 3 ) 2 Cl 2 (OH) 2 ] and c,c,t -[Pt(NH 3 ) 2 Cl 2 (OH) 2 ]·H 2 O 2 were prepared as previously described [21, 22]. Briefly, cisplatin was heated to 75 °C in the presence of excess aqueous hydrogen peroxide for 3 h. The solvent volume was reduced in vacuo and the resulting suspension cooled overnight to 4 °C.…”

Section: Methodsmentioning

confidence: 99%

Reinterpretation of the vibrational spectroscopy of the medicinal bioinorganic synthon c,c,t-[Pt(NH3)2Cl2(OH)2]

Johnstone

Lippard

2014

J Biol Inorg Chem

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The Pt(IV) complex c,c,t-[Pt(NH3)2Cl2(OH)2] is an important intermediate in the synthesis of Pt(IV) anticancer prodrugs and has been investigated as an anticancer agent in its own right. An analysis of the vibrational spectroscopy of this molecule was previously reported [Faggiani et al., 1982, Can. J. Chem. 60, 529] in which crystallographic determination of the structure of the complex permitted a site group approach. The space group, however, was incorrectly assigned. In the present study we have redetermined at high resolution crystal structures of c,c,t-[Pt(NH3)2Cl2(OH)2] and c,c,t-[Pt(NH3)2Cl2(OH)2]·H2O2, which enable discussion of the effect of hydrogen bonding on the N–H and O–H vibrational bands. The correct crystallographic site symmetry of the platinum complex in the c,c,t-[Pt(NH3)2Cl2(OH)2] structure is employed to conduct a new vibrational analysis using both group theoretical and modern DFT methods. This analysis reveals the nature and symmetry of the “missing band” described in the original publication and suggests a possible explanation for its disappearance.

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Section: Methodsmentioning

confidence: 99%

Reinterpretation of the vibrational spectroscopy of the medicinal bioinorganic synthon c,c,t-[Pt(NH3)2Cl2(OH)2]

Johnstone

Lippard

2014

J Biol Inorg Chem

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“…For potential platinum(IV) anticancer agents, the most widely used oxidizing agents are hydrogen peroxide 263 and chlorine. 264 These two molecules react with platinum(II) to give trans oxidative addition products (Scheme 18).…”

Section: Synthesis Of Platinum(iv) Anticancer Complexesmentioning

confidence: 99%

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

2013

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“…Oxidation of platinum(II) complexes with aqueous hydrogen peroxide affords trans -dihydroxoplatinum(IV) complexes . These complexes are useful for preparing a number of other derivatives, because the hydroxide ligands are nucleophilic and react with electrophiles, providing access to new compounds without the need for ligand-substitution chemistry .…”

Section: Platinum(iv) Anticancer Complexesmentioning

confidence: 99%

Monofunctional and Higher-Valent Platinum Anticancer Agents

2013

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Platinum compounds represent one of the great success stories of metals in medicine. Following the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a large number of cisplatin variants have been prepared and tested for their ability to kill cancer cells and inhibit tumor growth. These efforts continue today with increased realization that new strategies are needed to overcome issues of toxicity and resistance inherent to treatment by the approved platinum anticancer agents. One approach has been the use of so-called “non-traditional” platinum(II) and platinum(IV) compounds that violate the structure-activity relationships that governed platinum drug-development research for many years. Another is the use of specialized drug delivery strategies. Here we describe recent developments from our laboratory involving monofunctional platinum(II) complexes together with an historical account of the manner by which we came to investigate these compounds and their relationship to previously studied molecules. We also discuss work carried out using platinum(IV) prodrugs and the development of nanoconstructs designed to deliver them in vivo.

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Über Oxydation von Komplexverbindungen des Platins. Abhandlung I. Oxydation durch Wasserstoffsuperoxyd und Ozon

Cited by 14 publications

References 0 publications

Reinterpretation of the vibrational spectroscopy of the medicinal bioinorganic synthon c,c,t-[Pt(NH3)2Cl2(OH)2]

Reinterpretation of the vibrational spectroscopy of the medicinal bioinorganic synthon c,c,t-[Pt(NH3)2Cl2(OH)2]

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

Monofunctional and Higher-Valent Platinum Anticancer Agents

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