Über Porphyrine im Harn und im Kot

Vigliani, Enrico C.; Libowitzky, H.

doi:10.1007/bf01774681

Cited by 13 publications

(2 citation statements)

References 15 publications

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“…In a second group, however, a qualitative as well as a quantitative deviation from the normal metabolism of pigments exists. The anemia of lead (6,7,8) and salvarsan poisoning (9), and of certain hepatic cirrhoses, notably hemachromatosis, are of this type (1,10).…”

mentioning

confidence: 99%

The Excretion of Porphyrin in Refractory and Aplastic Anemia

Dobriner¹,

Rhoads²,

L³

1938

J. Clin. Invest.

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mentioning

confidence: 99%

The Excretion of Porphyrin in Refractory and Aplastic Anemia

Dobriner¹,

Rhoads²,

L³

1938

J. Clin. Invest.

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“…Six of these cases (7,9,15,17,21,23) are seen to present secondary anemia. Two others (13,16) in that a case with a normal urinary coproporphyrin excretion with a low total output and low fecal coproporphyrin excretion may be included as normal, although the calculated ratio may be elevated, e.g., Cases 12,13,15,16,17,21. In the tests of liver function done concomitantly with the porphyrin excretion studies, it appears that the ratio of urinary/fecal coproporphyrin output more closely approximates the clinical evaluation of disturbance of liver function and the blood chemistry changes than do certain of these tests.…”

Section: Resultsmentioning

confidence: 98%

The Urinary/Fecal Coproporphyrin Ratio in Liver Disease

Ms²,

Cf³

1941

J. Clin. Invest.

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In addition to the bile pigments, there are present in the urine and stool another series of pyrrole pigments, the porphyrins. Hemoglobin, myoglobin, and other respiratory pigments contain as their prosthetic group a porphyrin of Type III configuration. The porphyrin excreted in urine and feces by normal individuals, and in most pathological states, is coproporphyrin Type I. This substance cannot be derived by degradation of the Type III porphyrins present in the respiratory pigments (1). Dobriner and his associates have shown that coproporphyrin I is formed as a by-product in the course of hematopoiesis (2a, b, c). Furthermore, they showed that the rate of production and excretion of coproporphyrin I depends upon the activity of orderly hematopoiesis (3a, b, c). Dobriner (4a, b) and Watson (5a, b, c, d,e) have established that the excreted coproporphyrin is chiefly, if not entirely, endogenous in origin. The greater proportion of the coproporphyrin is excreted by the liver into the intestinal tract and is found in the stool. There is a similarity between the pathways of excretion of coproporphyrin and the bile pigments.Salkowski (7) and Garrod (9), in their early work on porphyrins, observed an increased urinary output of porphyrins in liver disease. Elevated urinary porphyrin excretion has been recorded in cases of passive congestion of the liver, cholangitis, catarrhal jaundice, luetic hepatitis, hemachromatosis, secondary carcinoma of the liver, acute and subacute liver atrophy, and cirrhosis (4a, 6, 10a, b, lla, b, 12, 13, 15, 16, 17, 18).No suitable fecal coproporphyrin studies have been reported in cases of diseases of the liver. Brugsch (1 la, b) and Vigliani (6) did not separate the fecal porphyrins into their components, hence their quantitative data for fecal porphyrin excretion comprise the total fecal porphyrins, and include deuteroporphyrin and protoporphyrin, which are partially exogenous in origin (4b, Se).Brugsch (lla, b) suggested that there might be value in the determination of the relative excretion of urinary and fecal porphyrins in cases of liver disease. It was reasoned that, since the coproporphyrin is excreted by the liver as well as by the kidney, the injured liver might be unable to excrete the total amount of coproporphyrin presented to it, and therefore this substance would accumulate in the blood stream and be excreted in the urine. Thus the urinary excretion would be increased at the expense of the fecal output. In cases of liver insufficiency, the ratio of urinary to fecal coproporphyrin should be elevated. In order to determine the amount of porphyrin cleared by the liver, only the coproporphyrin need be determined, since it alone is excreted in both urine and feces. METHODSThe quantitative separation methods for coproporphyrin used in our studies are those of Dobriner (4a, b, 20). Quantitative measurements were done by means of a spectroscopic colorimeter (21).All of the patients studied were on a regular diet. The entire urine and stool were collected for a period of seven...

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