'Über Tuberkulose' A tribute to robert koch's discovery of the tubercle bacillus, 1882

Grange, John M.; Bishop, Patrick

doi:10.1016/s0041-3879(82)80004-4

Cited by 14 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Its usage dates from the mid-nineteenth century with earlier terms having been consumption, phthisis, or if localized, scrofula. When Koch described in 1881 in Berlin his original findings in ''Ü ber Tuberculose'' [2], it represented a new recognition of the cause and pathology of the disease, and the term ''tuberculosis'' appears to have taken firm root then.…”

Section: Discussionmentioning

confidence: 99%

“…While the disease was described clinically in the nineteenth century after the cardinal discoveries of Robert Koch [2], the classification of the disease evolved over largely the twentieth century as the clinical manifestations of the disease were made evident. Most of the current classification remains anatomic, for example, pulmonary, extrapulmonary, pleural, urogenital, bone and joint, meningitis, miliary and disseminated all refer to the anatomic areas where disease is manifested.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The inconsistent definitions used for tuberculosis in the medical literature

Shandera

Merchant

2015

International Journal of Mycobacteriology

View full text Add to dashboard Cite

In order to assess the confusion attendant with current definitions of extrapulmonary tuberculosis, pleural and miliary disease, a set of 37 papers published which analyzed disease states were assessed for how the terms adhered to official definitions of the American Thoracic Society, the World Health Organization, and the Centers for Disease Control. The findings showed uncertainties in the classification of extrapulmonary disease, a frequent inconsistency in the inclusion of pleural disease within pulmonary rather than extrapulmonary disease, and the ambivalent use of the terms pleural and disseminated tuberculosis. Further attention by editors and authors is needed in the use of tuberculosis definitions.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The inconsistent definitions used for tuberculosis in the medical literature

Shandera

Merchant

2015

International Journal of Mycobacteriology

View full text Add to dashboard Cite

show abstract

“…Essa precocidade de reação reproduziu, em parte, o fenômeno descrito por Koch em 1890, quando observou experimentalmente que um grupo de cobaios inoculados 4 a 6 semanas antes com bacilos virulentos da tuberculose, ao serem reinoculados com cultura pura de micobactéria, apresentavam no ponto de inoculação, 1 a 2 dias depois, uma lesão mais escura que evoluía para necrose e cicatrização rápida, sem comprometimento de linfonodos adjacentes. No grupo de animais primo-inoculados, aparecia 10 a 14 dias depois uma área endurecida que evoluía com ulceração e necrose que persistia até a morte do animal 20 . No entanto, os resultados observados no presente estudo demonstraram que, apesar do processo inflamatório surgir precocemente, a cicatrização ocorreu lentamente, à semelhança do que se observa na primo-vacinação, não reproduzindo a seqüência esperada no estudo experimental de Koch.…”

Section: Discussionunclassified

Revacinação BCG em escolares: evolução da lesão vacinal entre 48 horas e 10 semanas

Ferreira¹,

Ferreira²,

Macedo³

et al. 2002

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

Objective: cutaneous reaction after BCG revaccination has been cause of concerns due its magnitude. Would it be intense enough to discourage its use in school-age children? The objective of this study is to describe the evolution of BCG vaccination site between 48 hours and 10 weeks post-revaccination.Methods: a descriptive cohort study was carried out involving 484 children between six and 11 years. The subjects were vaccinated with 0.1 mL of BCG-Moreau. Erythema, induration, pustule, ulcer, crust and final scar were measured within 48h, 72h and weekly until the tenth week, evaluated between July and December 1987. Epi Info 6.0 software was utilized to analyze frequencies, means, median and standard deviations.Results: induration was present in 99.1% and erythema in 91.6% of 438 children evaluated within 48h. Pustules were observed in the first week in 26.1% of 479 children. The first ulcers were seen during the second week. In the tenth week, 69.8% of 463 children showed crusts but only 29.2% completed the healing process.Conclusions: BCG revaccination in school-age children causes intense and early reaction that can be related to Koch phenomenon, even though it does not present the expected reduction in the healing period. The magnitude of the reaction is not enough to discourage its recommendation for school-age children. On the other hand, it is possible that the rapid inflammatory response is an indication of active immune response from the first vaccination. J Pediatr (Rio J) 2002; 78 (4): 289-94:BCG revaccination, cutaneous reaction, school-age children. ResumoObjetivo: a reação cutânea na revacinação BCG tem sido motivo de questionamentos dado à sua magnitude. Seria ela intensa o suficiente para desencorajar seu uso na idade escolar? O objetivo deste estudo é descrever o aspecto evolutivo da lesão vacinal entre 48 horas e a décima semana pós-revacinação.Métodos: estudo de coorte descritivo em que foram revacinadas 484 crianças entre seis e 11 anos de idade, com 0,1ml da vacina BCG Moreau, e aferidos eritema, enduração, pústula, úlcera, crosta e cicatriz em 48h, 72h e, semanalmente, até a décima semana de evolução, acompanhadas no período de julho a dezembro de 1997. Os dados foram informatizados em programa Epi-Info 6.0, avaliando-se freqüências, médias, medianas e desvios-padrões.Resultados: enduração estava presente em 99,1%, e eritema em 91,6% das 438 crianças avaliadas com 48h. Pústulas foram observadas na primeira semana em 26,1% de 479 crianças. Na segunda semana, já apareceram as primeiras úlceras. Na décima semana, 69,8% das 463 crianças presentes exibiam crostas, mas apenas 29,2% havia completado o processo de cicatrização.Conclusão: a revacinação BCG em escolares produz intensa e precoce reação, que pode ser atribuível ao fenômeno de Koch, mas sem a esperada redução no tempo de cicatrização. Se por um lado a magnitude da reação não chega a comprometer sua indicação na idade escolar, a pronta resposta inflamatória aponta para a ativa resposta imune possivelmente remanescente da primo-va...

show abstract

“…Robert Koch’s announcement of his discovery of the tubercle bacillus on the evening of 24 March, 1882 led to an unprecedented wave of research by the medical community (Grange & Bishop 1982), which in due time yielded the powerful tools now available for the prevention, diagnosis and treatment of tuberculosis. Over the last decade there have been quite remarkable advances in the understanding of the tubercle bacillus, and the disease that it causes, at the cellular and molecular levels.…”

Section: Introduction – Discovery Of the Tubercle Bacillusmentioning

confidence: 99%

The biosocial dynamics of tuberculosis

Grange

Kapata

Chanda

et al. 2009

Tropical Med Int Health

Self Cite

View full text Add to dashboard Cite

SummaryThe declaration by the WHO of tuberculosis as a 'global emergency' illustrates the paradox of tuberculosis. The treatment of this disease is a good example of 'evidence-based medicine', having been fine-tuned by numerous clinical trials. Modern short-course anti-tuberculosis therapy is among the most effective and cost-effective ways of saving and prolonging human life; yet, this disease is more prevalent today than in the days before the advent of effective therapy and is currently the cause of one in seven deaths and one in four preventable deaths among young adults. It would seem that something has gone seriously wrong and, to shed light on the cause, it is necessary to take a very broad historical look at the changing trends in the behaviour of the disease in communities worldwide and the attitudes of the various communities to the disease in their midst, not just to understand past mistakes, but to make sure we do not make the same mistakes now and in the future.

show abstract

'Über Tuberkulose' A tribute to robert koch's discovery of the tubercle bacillus, 1882

Cited by 14 publications

References 23 publications

The inconsistent definitions used for tuberculosis in the medical literature

The inconsistent definitions used for tuberculosis in the medical literature

Revacinação BCG em escolares: evolução da lesão vacinal entre 48 horas e 10 semanas

The biosocial dynamics of tuberculosis

Contact Info

Product

Resources

About