Überaktive Blase – wann welche Therapie?

Pannek, Jürgen

doi:10.1007/s00120-017-0522-1

Cited by 9 publications

(2 citation statements)

References 35 publications

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“…Botulinum toxin A is the only botulinum toxin currently approved for the treatment of urinary incontinence in OAB [6]. Botulinum neurotoxin A is derived from the gram-negative anaerobic bacterium Clostridium botulinum [7].…”

Section: Discussionmentioning

confidence: 99%

The application of botulinum toxin in the treatment of overactive bladder

Wójcik

Obuchowska

Ozga

et al. 2020

J Educ Health Sport

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Introduction:Urinary incontinence is an involuntary, decision-dependent urination that leads to partial or complete emptying of the bladder. The causes include overactive bladder syndrome, which is diagnosed on the basis of clinical symptoms, such as urgency to urinate, increased frequency of voiding, nocturia caused by increased reactivity of the detrusor muscle. Treatment of this condition includes, but is not limited to, pharmacotherapy, behavioral therapy, and pelvic floor exercises. It is also possible to use an innovative method of local injection of botulinum toxin into the bladder. It inhibits the release of acetylcholine, which results in the inhibition of the contractile activity of the detrusor muscle.The aim of the study: The purpose of the systemic review was to collect and analyze material of application of botulinum toxin in the treatment of urinary incontinence caused by overactive bladder.Material and methods: The work is a review of the literature on the use of botulinum toxin in the treatment of overactive bladder, published in 2002-2020.Description of the state of knowledge:The use of the described method gives long-lasting results compared to pharmacotherapy. In addition, it eliminates the side effects caused by drugs because the administration of drugs is reduced or discontinued. The use of botulinum toxin has many more benefits than simply improving the lives of people affected by urinary incontinence. When selecting the therapy, one should also pay attention to possible side effects resulting from the use of the described drug. Summary:Intravesical administration by means of botulinum toxin cystoscopy is a modern, safe, effective and minimally invasive method of treating urinary incontinence, possible on an outpatient basis, allowing to improve the urodynamic parameters. Side effects are very rare. The botulinum toxin serotype A used in this method is the most studied serotype used for therapeutic purposes. The conducted research shows that over 90% of women reported a clinically significant improvement in sexual function after using the method.

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Section: Discussionmentioning

confidence: 99%

The application of botulinum toxin in the treatment of overactive bladder

Wójcik

Obuchowska

Ozga

et al. 2020

J Educ Health Sport

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“…11 Gabapentin is also effective in neurogenic over-activity, because it can modulate irritability of the sacral reflex center. 12 The combined peripheral and central action of gabapentin may contribute to decrease in the occurrence of CRBD. Contrary to our results, there are studies which are unable to display a decrease in pain scores and analgesic requirement following surgery in patients administrated preoperative gabapentin.…”

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confidence: 99%

Effect of preoperative gabapentin after transurethral prostate resection under general anesthesia

Wang

Liu

et al. 2020

SMJ

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Objectives: To investigate whether preoperative oral gabapentin could reduce postoperative pain, analgesic consumption and the occurrence of catheter-related bladder discomfort (CRBD). Methods: In this study, participants randomly received either 600 mg gabapentin or placebo orally 2 h prior to transurethral prostate resection. Visual analogue scale and Ramsay sedation scale was utilized to assess pain intensity and sedation status after surgery. Intravenous 1.5 mg.kg-1 tramadol was used for postoperative analgesia. Pain intensity, sedation status, CRBD, tramadol consumption, side effects and the overall satisfaction degree were assessed and recorded for 48 h after tracheal extubation. Original Article Results: Ninety participants given gabapentin and 91 participants given placebo completed the study. Lower visual analogue scale scores, less tramadol consumption, longer time to the first analgesic requirement, lower incidence of CRBD and nausea and higher satisfaction degree were detected in the patients receiving gabapentin compared with the patients receiving placebo. Conclusion: Preoperative oral gabapentin reduced postoperative visual analogue scale scores, tramadol consumption and the occurrence rate of CRBD and nausea, and consequently, increased the degree of patients' satisfaction after transurethral prostate resection.

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