Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes

Comparative Effects of Statins on the Kidney Function in Patients with Type 2 Diabetes

“…Therefore, the other three statins are thought to more strongly inhibit the production of CoQ10 in extrahepatic cells than pravastatin. Recent basic studies have clearly shown that CoQ10 treatment prevents the development of DKD by reducing oxidative stress in db/db mice employed as a model of type 2 diabetes 21,22) . In light of these findings, the superiority of pravastatin demonstrated in the present study may be partly explained by differences in CoQ10 production in extrahepatic cells as a result of differences in lipophilicity.…”

ADCK4 “reenergizes” nephrotic syndrome

“…In mice with PDSS2 mutations, administration of CoQ 10 decreased albuminuria and interstitial nephritis (16). CoQ 10 also ameliorated albuminuria and mitochondrial changes in an experimental model of type 2 diabetes (db/db mice) (17,18). Importantly, Ashraf et al also showed that CoQ 10 was able to reverse the change in the podocyte migratory phenotype induced by ADCK4, indicating that mitochondrial dysfunction or reactive oxygen species generation is upstream of actin cytoskeleton changes.…”

Focal segmental glomerulosclerosis is associated with aPDSS2haplotype and, independently, with a decreased content of coenzyme Q10

“…The kd/kd mouse phenotype can be rescued to some extent by Q 10 supplementation (44) and to an even greater extent by probucol, which has the effect of increasing endogenous Q 9 content (12). Diabetic nephropathy in db/db mice can also be significantly ameliorated by Q 10 supplementation (50). It is also well established that mitochondrial deficits are associated with several animal models of hypoxia and acute kidney injury (13)(14)(15)62).…”