Ubiquitin in disguise unveils a cryptic binding site in 1.2-MDa anaphase-promoting complex/cyclosome

Abstract

Ubiquitin serves as a protein modifier and pervasive signaling molecule in eukaryotes, regulating major events throughout the lifetime of a cell, including pathways used for synthesis, repair, and degradation. Aptly named for its ubiquitous presence in human cells, proteomics studies